Abstract
Myocarditis is a challenging diagnosis due to the extreme diversity of clinical manifestations. The actual incidence of myocarditis is also difficult to determine as endomyocardial biopsy (EMB), the diagnostic gold standard, is used infrequently. Nevertheless, in up to 30 % of patients with biopsy-proven myocarditis, progression to dilated cardiomyopathy (DCM) can occur and is associated with a poor prognosis. Recent position statements of the European Society of Cardiology (ESC) and the American Heart Association vary widely with regard to indications for performing an EMB in these patients. This makes decision-making, in particular for general practitioners (GPs) and regional hospitals, difficult and unclear. Therefore, we will present a short summary of the ESC Working Group on Myocardial and Pericardial Diseases statement and our suggestions for GPs and regional hospitals for the diagnostic approach in patients with suspected myocarditis.
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
Introduction
Myocarditis is a challenging diagnosis due to the extreme diversity of clinical manifestations [1, 2]. The actual incidence of myocarditis is difficult to determine as endomyocardial biopsy (EMB), the diagnostic gold standard [1], is used infrequently [2]. The prognosis mainly depends on clinical presentation and EMB findings. Patients presenting with acute myocarditis and preserved left ventricular function have a good prognosis with a high rate of spontaneous improvement without sequelae [3, 4]. Interestingly, patients with fulminant viral myocarditis and haemodynamic compromise at presentation appear to have an excellent long-term prognosis and are more likely to experience complete recovery than patients with acute myocarditis [4, 5], if patients survive the acute phase supported by aggressive pharmacological and/or mechanical support. Nevertheless, in up to 30 % of patients with biopsy-proven myocarditis, progression to dilated cardiomyopathy (DCM) can occur and is associated with a poor prognosis [1, 2].
Recently, a 2013 position statement from the European Society of Cardiology (ESC) Working Group on Myocardial and Pericardial Diseases [6] recommended heart biopsy to be performed for all cases of suspected myocarditis, including most acute and chronic DCM. In contrast, the 2013 American College of Cardiology Foundation/American Heart Association (ACCF/AHA) [7] recommends that EMB should not be performed in the routine evaluation of patients with heart failure. How to find the desirable middle between these two extreme recommendations?
Here, we will present a short summary of the ESC Working Group on Myocardial and Pericardial Diseases statement and our suggestions for general practitioners and regional hospitals for the diagnostic approach in patients with suspected myocarditis.
Definitions
In line with the statement of the ESC Working Group, we also acknowledge that there is some confusion about the terms DCM, inflammatory cardiomyopathy (CMP) and myocarditis. DCM is a clinical diagnosis based on morphological and functional characterisation of the left ventricle [1]; inflammatory CMP is both a histological and a functional diagnosis characterised by myocarditis in association with systolic and/or diastolic dysfunction [1]. Myocarditis is an inflammatory disease of the myocardium diagnosed by established histological (Dallas criteria) [8], immunological, and immunohistochemical criteria (>14 leucocytes/mm2 including up to 4 monocytes/mm2 with the presence of CD3 positive T-lymphocytes >7 cells/mm2) [9]. The histological diagnosis of myocarditis can be classified according to the type of inflammatory cell infiltrates: lymphocytic, eosinophilic, polymorphic, giant cell myocarditis, and cardiac sarcoidosis. The ESC task group also recommends the use of subsets of myocarditis or inflammatory cardiomyopathy:
-
Viral myocarditis: Histological evidence for myocarditis associated with positive viral polymerase chain reaction (PCR).
-
Autoimmune myocarditis: Histological myocarditis with negative viral PCR, with or without serum cardiac autoantibodies (AABs).
-
Viral and immune myocarditis: Histological myocarditis with positive viral PCR and positive AABs.
Clinical presentation
The clinical manifestations of myocarditis may range from subclinical disease to fulminant heart failure. A summary of clinical presentations of patients with biopsy-proven myocarditis is shown in Table 1.
Diagnosis
Several non-invasive diagnostic modalities, including cardiac magnetic resonance imaging (CMR), can be helpful in the diagnosis of myocarditis; however we emphasise that EMB remains the gold standard for the diagnosis of definite myocarditis. Nevertheless, we are aware that performing EMB is not routine practice in patients with suspected myocarditis. Therefore, we will present our suggestions regarding the first-line diagnostic steps in suspected myocarditis patients and when to refer these patients to a tertiary hospital specialised in EMB.
First-line tests in patients with suspected myocarditis
-
Electrocardiogram (ECG)
The ECG is usually abnormal in myocarditis although ECG signs are neither specific nor sensitive [3]. Diffuse concave (rather than convex in myocardial ischaemia) ST-T segment elevations without reciprocal changes and non-specific T-wave changes are suggestive for myocarditis [10].
-
Echocardiography
Echocardiography is useful to exclude other causes of heart failure and identify ventricular thrombi; however, there are no specific echocardiographic features of myocarditis. As known, segmental or global wall motion abnormalities can mimic myocardial infarction. Patients with fulminant myocarditis tend to present with a non-dilated, thickened, and hypocontractile left ventricle, whereas patients with less acute myocarditis present with greater left ventricular dilation and normal wall thickness. Right ventricular dysfunction is uncommon but an important predictor of death or cardiac transplantation. Moreover, echocardiography is useful to monitor changes in cardiac chamber size, wall thickness, ventricular function, and pericardial effusions.
-
CMR
State-of-the-art CMR in suspected myocarditis can localise tissue injury, where different virus types seem to influence the pattern of myocardial injury [11, 12]. Moreover, CMR can quantitate tissue injury, including oedema, hyperaemia, and fibrosis, and can support the diagnosis of myocarditis (Lake Louis criteria) [11, 12]. Based on the Lake Louis criteria, when two or more of the three criteria are positive, myocardial inflammation can be predicted with a diagnostic accuracy of 78 % [11]. Timing is of crucial importance and will depend on the local availability, expertise and clinical condition of the patient. It is reasonable to perform CMR prior to EMB in clinically stable patients and it should not be performed in life-threatening presentations where EMB is urgently indicated [13].
-
Biomarkers
The sensitivity of cardiac biomarkers of myocardial injury varies depending on the time from symptom onset to testing and the cut-off values used [6].
Erythrocyte sedimentation rate and C-reactive protein levels are often elevated in myocarditis, but they do not confirm the diagnosis. Cardiac troponins are more sensitive than creatine kinase levels, however are also non-specific and when normal do not exclude myocarditis. The same is true for cardiac hormones such as brain natriuretic peptides, circulating cytokines, and markers related to extracellular matrix degradation. Furthermore, viral serology is of limited utility in the diagnosis of viral myocarditis due to a high prevalence of circulatory IgG antibodies to cardiotropic viruses in the general population without viral heart disease. Serum cardiac AABs to various cardiac and muscle-specific autoantigens can be of diagnostic and prognostic value, however are not commercially available and/or validated yet.
New proposed criteria for clinically suspected myocarditis
Myocarditis should be suspected in the presence of:
-
One or more of the clinical presentations in Table 1, with or without ancillary features
And
-
One or more of the diagnostic criteria from different categories (I to IV) in Table 2
Or
-
When the patient is asymptomatic, 2 or more diagnostic criteria from different categories (I to IV)
Our suggestions include that all patients with clinically suspected myocarditis should be admitted and considered for selective coronary angiography, in line with the recommendations from the ESC Working Group. We differ from the perspective of both the ESC and ACCF/AHA regarding the indication for EMB in patients with suspected myocarditis. We recommend the golden mean between both statements and use a more practical approach, particularly for patients presenting to GPs and/or regional hospitals that often have no access to state-of-the-art CMR or cannot safely perform EMB. Therefore, referral for EMB in acute suspected myocarditis patients (point 1, 2 & 4 in Table 1) is recommended in the case of:
-
A life-threatening arrhythmia
-
LV dysfunction that does not improve 4–5 days after onset of symptoms
-
LV dysfunction that progressively deteriorates within 4–5 days after onset of symptoms
-
Recurrent myocarditis
Clinical management and outcome
Treatment strategies consist of both conventional therapy and in case of performing an EMB aetiology-based treatment. Conventional treatment consists of ACE inhibitors, angiotensin II receptor blockers, aldosterone antagonists and beta-blockers in case of heart failure, according to the ESC guidelines for heart failure. In line with these recommendations, both ACE inhibitors and beta-blockers were independently associated with LV function recovery in biopsy-proven acute myocarditis patients with LVEF <50 % [4]. Although there is a lack of large multicentre trials investigating aetiology-based treatment, several strategies can be considered based on expert consensus. These include immunomodulatory therapy (antiviral therapy, high-dose intravenous immunoglobulins, immunoadsorption) or immunosuppressive therapy (in virus-negative and AAB-positive myocarditis). Serial EMBs are recommended to evaluate the effect of these aetiology-based treatment strategies and should be modified accordingly. Notably, all recurrences of suspected myocarditis should be treated as the initial episode, wherein EMB is highly recommended to investigate a possible cause.
In general, approximately 50 % of patients presenting with acute myocarditis will spontaneously improve without sequelae within 2–4 weeks; however about 25 % will develop persistent cardiac dysfunction and up to 25–30 % may deteriorate and either die or progress to end-stage DCM with the need for heart transplantation (HTx) [1–4]. Concordantly, in a recent large study of biopsy-proven acute myocarditis patients, the mortality rate after a mean of 12 years of follow-up was 30 % and 10 % underwent HTx [4]. Of note, events still occurred after 8 years of follow-up, particularly in those patients presenting with rhythm disturbances [4]. Finally, EMB evidence of giant cell myocarditis has the highest 1-year mortality and HTx rate of ~70 %, with recurrences in up to 25 % in the allograft heart [14]. Therefore, unless otherwise indicated, long-term non-invasive cardiological follow-up is recommended in all patients who have experienced myocarditis [6].
Conclusion
The diagnosis of myocarditis remains challenging and the exact approach varies, as reflected by the different recommendations of both the ESC and ACCF/AHA. Particularly in the setting of GPs or regional hospitals, timing of referral of a suspected myocarditis patient to a tertiary hospital remains unclear. Therefore, we have suggested a more practical approach for this matter in order to standardise referral of suspected myocarditis patients and improve patient care. Nevertheless, multicentre randomised trials are needed to provide further insight in aetiology-based treatments which may improve outcome in these predominantly young patients.
References
Richardson P, McKenna W, Bristow M, et al. Report of the 1995 world health organization/international society and federation of cardiology task force on the definition and classification of cardiomyopathies. Circulation. 1996;93:841–2.
Kindermann I, Barth C, Mahfoud F, et al. Update on myocarditis. J Am Coll Cardiol. 2012;59:779–92.
Caforio AL, Calabrese F, Angelini A, et al. A prospective study of biopsy-proven myocarditis: prognostic relevance of clinical and aetiopathogenetic features at diagnosis. Eur Heart J. 2007;28:1326–33.
Anzini M, Merlo M, Sabbadini G, et al. Long-term evolution and prognostic stratification of biopsy-proven active myocarditis. Circulation. 2013
McCarthy 3rd RE, Boehmer JP, Hruban RH, et al. Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. N Engl J Med. 2000;342:690–5.
Caforio AL, Pankuweit S, Arbustini E, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2013
Yancy CW, Jessup M, Bozkurt B, et al. ACCF/AHA guideline for the management of heart failure: A report of the American college of cardiology foundation/American heart association task force on practice guidelines. J Am Coll Cardiol 2013; 2013(Jun 5).
Aretz HT, Billingham ME, Edwards WD, et al. Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol. 1987;1:3–14.
Kindermann I, Kindermann M, Kandolf R, et al. Predictors of outcome in patients with suspected myocarditis. Circulation. 2008;118:639–48.
Morgera T, Di Lenarda A, Dreas L, et al. Electrocardiography of myocarditis revisited: clinical and prognostic significance of electrocardiographic changes. Am Heart J. 1992;124:455–67.
Friedrich MG, Sechtem U, Schulz-Menger J, et al. Cardiovascular magnetic resonance in myocarditis: A JACC white paper. J Am Coll Cardiol. 2009;53:1475–87.
Olimulder MA, van Es J, Galjee MA. The importance of cardiac MRI as a diagnostic tool in viral myocarditis-induced cardiomyopathy. Neth Heart J. 2009;17:481–6.
Cooper LT, Baughman KL, Feldman AM, et al. The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Endorsed by the heart failure society of america and the heart failure association of the european society of cardiology. J Am Coll Cardiol. 2007;50:1914–31.
Cooper Jr LT, ElAmm C. Giant cell myocarditis. Diagnosis and treatment. Herz. 2012;37:632–6.
Acknowledgments
This work was supported by the European Commission’s Seventh Framework programme under grant agreement N° 305507 (HOMAGE), N° 305507 (FIBROTARGETS) and N° 261409 (MEDIA), and the Marie-Curie Industry, Academy Pathways and Partnerships (CARDIOMIR) N°285991. It was supported by research grants from the Netherlands Organization for Scientific Research (NWO) Vidi 91796338 (Dr Heymans). We acknowledge the support from the Netherlands Cardiovascular Research Initiative: the Dutch Heart Foundation, the Dutch Federation of University Medical Centres, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON 2011-11 ARENA).
Conflict of interest
None declared.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
About this article
Cite this article
Hazebroek, M.R., Everaerts, K. & Heymans, S. Diagnostic approach of myocarditis: strike the golden mean. Neth Heart J 22, 80–84 (2014). https://doi.org/10.1007/s12471-013-0499-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12471-013-0499-3