Abstract
In order to reduce the damage to tissue and fill the interstices between fibers, multifilament sutures are frequently treated with certain coating materials. The objective of this study was to create and characterize dopamine hydrochloride (DA) and carboxymethyl chitosan (CMCS) coatings on surgical sutures and investigate their effects on the frictional performance of the surgical sutures during sliding through a skin substitute. The effects of the treatment on the physical and chemical characteristics of the surgical sutures were evaluated. The friction force of the surgical sutures during sliding through the skin substitute was experimentally determined using a penetration friction apparatus. The coefficient of friction (COF) was calculated using a linear elastic model and was used to estimate the frictional behavior of the surgical suture-skin interactions.
The results showed that the DA coating could evenly deposit on the surface of the etched multifilament surgical suture surfaces in a weakly alkaline buffer solution. The CMCS coating material could form a uniform film on the surface of the sutures. Minor changes in the surface roughness of the multifilament surgical sutures with different treatments occurred in this study. The friction force and the COF of the multifilament surgical sutures with DA and CMCS coating showed little change when compared with untreated multifilament surgical sutures.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Raes G, Röder H L. The relation between fibre friction and the behaviour of fibres and yarns during processing. J Text Inst Proc46(1): P84–P100 (1955)
Zhang G Q, Ren T H, Zeng X Q, Van Der Heide E. Influence of surgical suture properties on the tribological interactions with artificial skin by a capstan experiment approach. Friction5(1): 87–98 (2017)
Apt L, Henrick A. “Tissue-drag” with polyglycolic acid (Dexon) and polyglactin 910 (Vicryl) sutures in strabismus surgery. J Pediatr Ophthalmol13(6): 360–364 (1976)
Gilbert J L. Wound closure biomaterials and devices. Shock11(3): 226 (1999)
Moy R L, Waldman B, Hein D W. A review of sutures and suturing techniques. J Dermatol Surg Oncol18(9): 785–795 (1992)
Rao Y Q, Farris R J. A modeling and experimental study of the influence of twist on the mechanical properties of highperformance fiber yarns. J Appl Polym Sci77(9): 1938–1949 (2000)
Ajmeri J R, Ajmeri C J. Surgical sutures: the largest textile implant material. In Medical Textiles and Biomaterials for Healthcare. Anand S C, Kennedy J F, Miraftab M, Rajendran S, Eds. Boca Raton: Woodhead Publishing, 2006: 432–440.
Storch M, Scalzo H, Van Lue S, Jacinto G. Physical and functional comparison of Coated VICRYL* Plus Antibacterial Suture (coated polyglactin 910 suture with triclosan) with Coated VICRYL* Suture (coated polyglactin 910 suture). Surg Infect3 Suppl 1: S65–S77 (2002)
Lv J C, Zhou Q Q, Liu G L, Gao D W, Wang C X. Preparation and properties of polyester fabrics grafted with O-carboxymethyl chitosan. Carbohydr Polym113: 344–352 (2014)
Hernandez-Richter T, Schardey H, Löhlein F, Heiss M, Redondo-Müller M, Hammer C, Schildberg F W. The prevention and treatment of vascular graft infection with a triclosan (Irgasan®)-bonded Dacron graft: an experimental study in the pig. Eur J Vasc Endovasc Surg20(5): 413–418 (2000)
Zhang S W, Liu X L, Wang H L, Peng J, Wong K K Y. Silver nanoparticle-coated suture effectively reduces inflammation and improves mechanical strength at intestinal anastomosis in mice. J Pediatr Surg49(4): 606–613 (2014)
Li Y, Kumar K N, Dabkowski J M, Corrigan M, Scott R W, Nusslein K, Tew G N. New bactericidal surgical suture coating. Langmuir28(33): 12134–12139 (2012)
Chen X J, Hou D D, Wang L, Zhang Q, Zou J H, Sun G. Antibacterial surgical silk sutures using a high-performance slow-release carrier coating system. ACS Appl Mater Interfaces7(40): 22394–22403 (2015)
Walling H W, Christensen D R, Arpey C J, Whitaker D C. Surgical pearl: lubrication of polyglactin suture with antibiotic ointment. J Am Acad Dermatol52(1): 136–137 (2005)
Chen X J, Hou D D, Tang X Q, Wang L. Quantitative physical and handling characteristics of novel antibacterial braided silk suture materials. J Mech Behav Biomed Mater50: 160–170 (2015)
Ku S H, Ryu J, Hong S K, Lee H, Park C B. General functionalization route for cell adhesion on non-wetting surfaces. Biomaterials31(9): 2535–2541 (2010)
Barras A, Lyskawa J, Szunerits S, Woisel P, Boukherroub R. Direct functionalization of nanodiamond particles using dopamine derivatives. Langmuir27(20): 12451–12457 (2011)
Lee H, Dellatore S M, Miller W M, Messersmith P B. Mussel-inspired surface chemistry for multifunctional coatings. Science318(5849): 426–430 (2007)
Yan J, Yang L P, Lin M F, Ma J, Lu X H, Lee P S. Polydopamine spheres as active templates for convenient synthesis of various nanostructures. Small9(4): 596–603 (2013)
Jayakumar R, Prabaharan M, Nair S V, Tokura S, Tamura H, Selvamurugan N. Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications. Prog Mater Sci55(7): 675–709 (2010)
Viju S, Thilagavathi G. Effect of chitosan coating on the characteristics of silk-braided sutures. J Ind Text42(3): 256–268 (2013)
Zhang G Q, Ren T H, Lette W, Zeng X Q, van der Heide E. Development of a penetration friction apparatus (PFA) to measure the frictional performance of surgical suture. J Mech Behav Biomed Mater74: 392–399 (2017)
Shergold O A, Fleck N A. Experimental investigation into the deep penetration of soft solids by sharp and blunt punches, with application to the piercing of skin. J Biomech Eng127(5): 838–848 (2005)
Azar T, Hayward V. Estimation of the fracture toughness of soft tissue from needle insertion. In Proceedings of the 4th International Symposium on Biomedical Simulation, London, UK, 2008: 166–175.
Shergold O A, Fleck N A, Radford D. The uniaxial stress versus strain response of pig skin and silicone rubber at low and high strain rates. Int J Impact Eng32(9): 1384–1402 (2006)
Peng F, Olson J R, Shaw M T, Wei M. Influence of pretreatment on the surface characteristics of PLLA fibers and subsequent hydroxyapatite coating. J Biomed Mater Res B Appl Biomater88B(1): 220–229 (2009)
De Simone S, Gallo A L, Paladini F, Sannino A, Pollini M. Development of silver nano-coatings on silk sutures as a novel approach against surgical infections. J Mater Sci: Mater Med25(9): 2205–2214 (2014)
Cohen R E, Hooley C J, McCrum N G. Viscoelastic creep of collagenous tissue. J Biomech9(4): 175–184 (1976)
Chen B S, Gu K C, Fang J H, Wu J, Wang J, Zhang N. Tribological characteristics of monodispersed cerium borate nanospheres in biodegradable rapeseed oil lubricant. Appl Surf Sci353: 326–332 (2015)
Wei Q, Zhang F L, Li J, Li B J, Zhao C S. Oxidant-induced dopamine polymerization for multifunctional coatings. Polym Chem1(9): 1430–1433 (2010)
Brugnerotto J, Lizardi J, Goycoolea F M, Argüelles-Monal W, Desbrières J, Rinaudo M. An infrared investigation in relation with chitin and chitosan characterization. Polymer42(8): 3569–3580 (2001)
Chen X G, Park H J. Chemical characteristics of O-carboxymethyl chitosans related to the preparation conditions. Carbohydr Polym53(4): 355–359 (2003)
Zheng M L, Han B Q, Yang Y, Liu W S. Synthesis, characterization and biological safety of O-carboxymethyl chitosan used to treat Sarcoma 180 tumor. Carbohydr Polym86(1): 231–238 (2011)
Rodeheaver G T, Thacker J G, Owen J, Strauss M, Masterson T, Edlich R F. Knotting and handling characteristics of coated synthetic absorbable sutures. J Surg Res35(6): 525–530 (1983)
Acknowledgments
The authors are grateful to Marie Curie CIG (Grant no. PCIG10-GA-2011-303922), the Shanghai Natural Science Foundation (Grant no. 17ZR1442100), and the Shanghai Municipal “Science and Technology Innovation Action Plan” International Cooperation Project (no. 15540723600) for the financial support.
Author information
Authors and Affiliations
Corresponding authors
Additional information
Xiangqiong ZENG. She received her master degree in applied chemistry in 2003 and Ph.D degree in material science in 2006 from Shanghai Jiao Tong University. Then, she worked at Johnson & Johnson consumer groupduring 2006−2010 as staff scientist on skin care technology. From 2011−2015, she was appointed as a tenure track assistant professor at the University of Twente, working on skin tribology. Currently, she is a full professor at Shanghai Advanced Research Institute, Chinese Academy of Sciences. Her research interests are functional interface materials for biotribology and aqueous lubrication, including active control of friction and wear by surface and interface design of skin contacting materials and medical devices, by test methodology development with the design of instrument and bio-inspired human tissue model, and by additive and emulsion development for aqueous lubrication.
Gangqing ZHANG. He received his master degree in chemistry and chemical Engineering in 2013 from Qingdao University, Qingdao, China. After then, he was a Ph.D student in Key Laboratory of Thin Film and Microfabrication Technology (Ministry of Education) at Shanghai Jiao Tong University, China. Meanwhile, he was also a Ph.D student in mechanical engineering at University of Twente, Enschede, the Netherlands. He has recently obtained his Ph.D degree in the two universities. His research interests include biotribology of medical material and development of lubricants, and development of medical biomaterials.
Rights and permissions
Open Access: The articles published in this journal are distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
About this article
Cite this article
Zhang, G., Zheng, G., Ren, T. et al. Dopamine hydrochloride and carboxymethyl chitosan coatings for multifilament surgical suture and their influence on friction during sliding contact with skin substitute. Friction 8, 58–69 (2020). https://doi.org/10.1007/s40544-018-0242-6
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40544-018-0242-6