Abstract
Clinical forensic assessments of injuries’ life-threatening danger may have an impact on the legal aftermath following a violent assault. The pursuit of evidence-based guidelines should ensure a user-independent and reproducible forensic practice. However, does it? The aim of this study was to evaluate the forensic life-threatening danger assessments after a protocol implementation in 2016. The evaluation concerned usability and reproducibility of the protocol, and its influence on assessment severity. We analyzed the level of inter- and intra-rater agreement using 169 blinded, prior-protocol cases that were reassessed by two forensic specialists. We compared assessment made the year before and after protocol implementation (n = 262), and the forensic specialists’ reassessments with the prior-protocol cases’ original assessments (n = 169). Whether to make an assessment, the levels of agreement varied between weak agreement (inter-rater, Κ = 0.43; assessor 1, Κ = 0.57) and strong agreement (assessor 2, Κ = 0.90). Regarding severity, the levels of agreement varied between strong agreement (inter-rater, Κ = 0.87; assessor 1: Κ = 0.90) and almost perfect agreement (assessor 2: Κ = 0.94). The assessments were statistically significant redistributed after the implementation (chi-square test: p < 0.0001). The proportion of cases assessed as having not been in life-threatening danger increased from 9 to 43%, and moderate severity assessments decreased from 55 to 23%. Of the moderate severity assessments, 55% were reassessed as having not been in life-threatening danger. The protocol ensured independent and reproducible assessments when the forensic specialists agreed on making one. The protocol resulted in less severe assessments. Future studies should examine the reliability of the protocol and its consequences for legal aftermaths.
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Introduction
Forensic life-threatening danger assessments
The assessment of life-threatening danger or seriousness of documented injuries in clinical forensic medicine (CFM) is heterogeneous and lacks underlying evidence-based validation [1]. Studies discussing these types of assessments [2, 3] may not present their practice guidelines in detail or provide the underlying evidence-based validation, and this complicates any assessment of the scientific background or comparison of national practices. Life-threatening danger assessments are also part of the Danish standardized victim CFM examination [4], which is requested by the police authorities in cases of serious violence, as defined in the Danish Penal Code [5]. The CFM examination may contribute to the police investigation by clarifying some of the case circumstances, including the extent and dangerousness of the injuries. The latter may also have an impact on the decisions regarding the provisional charges by the police or the formal charges by the prosecution service against a suspected perpetrator [6].
Implementation of a Danish protocol for assessment of life-threatening danger
The use of clinical guidelines has increased over many decades. These guidelines can facilitate the translation of medical research into recommendations, thereby closing the gap between daily practice and what is supported by a critical appraisal of scientific evidence, i.e., evidence-based guidelines [7]. Well-constructed and properly implemented guidelines should guide less experienced clinicians and convert experienced clinicians with outdated practices and should generally secure a standardized approach [7,8,9]. Expert opinions are not evidence, but they are of the utmost importance when developing guidelines [10].
On September 13, 2016, a revised local protocol was implemented as a result of a meeting between the Danish Medico-Legal Council and the Chief Forensic Pathologists in Denmark. This protocol is now used by the Department of Forensic Medicine, University of Copenhagen, in Eastern Denmark for life-threatening danger assessments [4]. Before the protocol implementation, the life-threatening danger assessments could be characterized as apprenticeship based on the expert opinions of the senior board-certified forensic specialists, and an educational textbook [11]. Apart from a terminology change (see Fig. 1 for an overview), the protocol specify that the Danish forensic life-threatening danger assessments should supersede the individual board-certified forensic specialists’ expert opinions and be based only on the documented, prior-to-treatment anatomical injuries and subsequent health state, and not on a hypothetical outcome of the violent act, i.e., tort-underlying argumentation. Thus, the local protocol should ensure inter-observer independent and reproducible life-threatening danger assessments, based on clinical-underlying argumentation. By removing the somewhat more legally grounded tort-underlying argumentation, this protocol could also be perceived as making the life-threatening danger assessments less severe.
Despite the potential conflict between the hospital personnel and the forensic specialists’ tasks, the cooperation works well and the forensic specialists in Eastern Denmark are mostly able to document the injuries before they are washed, stitched, and banded [4]. Information about the subsequent health state is available when the police, with a written consent from the examined individual, request hospital records from the healthcare sector [12]. The forensic specialists also document verbal communication with the hospital personnel during the CFM examinations. In cases with no objective signs of the assault, the argumentation that underlies the life-threatening danger assessment may lean on reported fatal outcomes in the scientific literature. This we refer to as literary-underlying argumentation.
The revised, local protocol includes a subdivision for penetrating injuries (i.e., sharp force injuries and gunshot wounds), with highlighted clinical-underlying criteria for the three possible life-threatening danger assessments. “Has not been in life-threatening danger” (NLD) is used when the CFM examined that the individual had stable vital parameters, sparse hemorrhage, no blood transfusion, no treatment except suturing, etc., whereas “could have been in life-threatening danger” (CLD) is used in cases with injuries that necessitated treatment, and “has been in life-threatening danger” (LD) is used when emergency treatment, surgery, blood transfusion, etc. were required. The abbreviations are listed in Table 1, and the subdivision of the protocol concerning the assessments of penetrating injuries is presented in English in Online Resource 1.
Aim
The implementation of the revised local protocol raises two important questions: Given that the Eastern Danish forensic specialists adopted the new protocol, did it result in inter-observer independent and reproducible assessments, and did the protocol influence the severity of the life-threatening danger assessments of penetrating injuries? Therefore, the aim of this study was to evaluate the changed forensic practice regarding the life-threatening danger assessments of penetrating injuries in Eastern Danish forensics in terms of the usability and reproducibility of this subdivision of the new protocol and its influence on the assessment severity.
Materials and methods
From a digital forensic case management system, we registered 3031 forensically examined individuals in Eastern Denmark from January 1, 2012, to December 31, 2017, in a CFM database. Inclusion criteria for the CFM database were CFM examinations of living individuals aged 15 or older, examined after a physical and/or sexual assault, from the geographical area, and in the time span defined above. Exclusion criteria were other kinds of forensic examinations (e.g., age evaluations, torture cases, individuals sampled solely for biological materials, and cases where the forensic reports were canceled or missing). As we evaluate the subdivision of the implemented protocol concerning penetrating injuries, we included only victim cases with documented sharp force injuries and gunshot wounds.
Registered variables and statistics
When perusing the forensic reports, we registered information about the examination type, documented injuries, available hospital records, verbal communication with the hospital personnel from the healthcare sector, and, finally, the life-threatening danger assessment and its basis. Statistics were performed in SAS (SAS Enterprise Guide 7.15, 2017, SAS Institute Inc., Cary, NC, USA). The specific statistical analyses used are presented below. Figure 1 and Table 1 summarize the variables, possible entries, and the statistical analyses used.
Articulated research questions
Using the following research questions, we evaluated the effect of the protocol implementation:
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1.
Is the implemented protocol inter-observer independent and reproducible?
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2.
Did the new protocol influence the severity of the life-threatening danger assessments compared to the former practice?
Research question 1: Is the implemented protocol inter-observer independent and reproducible?
We selected 169 prior-protocol victim cases with documented penetrating injuries from the CFM database, 100 randomly selected sharp force injury cases [13], and all cases with gunshot wounds. Two board-certified forensic specialists (assessors 1 and 2) reassessed the 169 cases (see Fig. 1). After a minimum 2-month interval, they repeated the reassessment in 59 of the cases, which were randomly selected [13]. The reassessment process was time-consuming with approximately four reassessments per hour. Thus, we included 25% of the CFM examined victims with sharp force injuries (N = 396 cases in total). When reassessing the life-threatening danger, the assessors had the relevant original case material available (i.e., the anamnesis, objective forensic examination, obtained hospital records, and police report). We removed the original forensic report conclusion concerning the life-threatening danger assessment. For the inter-rater agreement analyses, we provided the assessors with a batch of approximately 60 cases each time. Possible reassessments were a priori defined as not possible (NP), not relevant (NR), NLD, CLD, and LD (see Fig. 1 and Table 1). The assessors were instructed to use NR when they found that the documented penetrating injuries were under a subjective lower threshold limit and/or a life-threatening danger assessment was not relevant for the case.
We tested the inter-rater agreement of the reassessments between assessors 1 and 2, and the intra-rater agreement (i.e., the test-retest reliability) of the reassessment for each assessor. We did not subdivide the statistical analyses based on the two types of penetrating injuries as the clinical-underlying criteria for the life-threatening danger assessments are the same for both sharp force injuries and gunshot wounds. Thus, we did not expect a reassessment difference between the two types of penetrating injuries.
The inter- and intra-rater analyses were a two-step process. Using Cohen’s kappa [14] and McNemar’s test [15], we tested the agreement of whether to make a life-threatening danger assessment (i.e., NP + NR versus NLD + CLD + LD). Second, we used weighted kappa [16, 17] and Bowker’s test of symmetry [18] to test the agreement of the life-threatening danger assessment severity (i.e., NLD versus CLD versus LD). Instead of using the SAS default Cicchetti-Allison linear weights [19], we chose to use the Fleiss-Cohen quadratic weights [16]. Thus, for the weighted kappa analyses, we used the AGREE(WT=FC) in the table statement in SAS [20]. We used McHugh’s interpretation of the kappa values for the level of agreement: 0–0.20 none, 0.21–0.39 minimal, 0.40–0.59 weak, 0.60–0.79 moderate, 0.80–0.90 strong, and above 0.90 almost perfect [21].
Research question 2: Did the new protocol influence the severity of the life-threatening danger assessments compared to the former practice?
For this part of the study, we identified 262 forensically examined victims with penetrating injuries from September 13, 2015, to September 12, 2017 (i.e., the examinations performed in the year before and after the protocol implementation date; see Fig. 1) in the CFM database. We registered the availability of hospital records from the healthcare sector, verbal communication with the hospital personnel during the CFM examination, and the argumentation underlying the forensic life-threatening danger assessments.
Original life-threatening danger assessments 1 year before and after the protocol implementation
We compared the proportions of the cases with and without life-threatening danger assessments 1 year before and 1 year after the protocol implementation. Using a two-way chi-square test, we tested for a statistically significant distribution of the multinomial original life-threatening danger assessments between the two groups of our independent variable (i.e., the year before and the year after). In the chi-square test, we merged PLD and CLD and MLD and LD, to account for the terminology change (see Table 1).
Comparison of the original life-threatening danger assessments and reassessment severity
In order to examine whether the severity of the original life-threatening danger assessments would have differed had the protocol existed at the time of the CFM examinations, we compared the assessors’ 169 prior-protocol reassessed cases with the original life-threatening danger assessments. As the assessors were instructed to reassess the included cases, NA was not an option. Instead, they could state that it was not possible (NP) or not relevant (NR) to make a life-threatening danger assessment (see Fig. 1 and Table 1). We used descriptive statistics to compare the original life-threatening danger assessments and the reassessments.
Results
Research question 1: Is the implemented protocol inter-observer independent and reproducible?
The original life-threatening danger assessments for the 100 randomly selected victim cases with sharp force injuries were 24 NAs, 2 NLDs, 57 PLDs, 0 CLDs, 13 MLDs, 2 LDs, and 2 Ds. The distribution of the included victim cases with gunshot wounds (N = 67) was 10 NAs, 2 NLDs, 36 PLDs, 2 CLDs, 10 MLDs, 5 LDs, and 2 Ds. Two PLD cases had both documented sharp force injuries and gunshot wounds.
Inter-rater agreement
Comparison of the reassessments made by assessors 1 and 2 revealed agreement in 72% of the cases (Table 2). Table 2 shows that Cohen’s kappa for the inter-rater agreement analysis on whether to make a life-threatening danger assessment (NLD, CLD, and LD) or not (NP and NR) was 0.43 (95% CI, 0.23 to 0.62; p < 0.0001). According to McHugh, this is a weak level of agreement (0.40–0.59). The McNemar’s test was not statistically significant (p = 0.2008); therefore, we cannot reject that the reassessments made by assessor 1 and assessor 2 had equal distributions. The weighted kappa coefficient for the 136 included cases for the inter-rater severity agreement analysis was 0.87 (95% CI, 0.82 to 0.93; p < 0.0001). According to McHugh, this is a strong level of agreement (0.80–0.90). Bowker’s test of symmetry was statistically significant (p = 0.0062); therefore, we can reject that the raters had the same propensity to assess the degree of severity of the injuries. See Table 3.
Intra-rater agreement
Regarding making a life-threatening danger assessment, the Cohen’s kappa coefficients for assessors 1 and 2 were 0.57 (95% CI, 0.26 to 0.88; p < 0.0001) and 0.90 (95% CI, 0.71 to 1.00; p < 0.0001), respectively. The McHugh’s interpretation is the same as for the inter-rater agreement analyses. The McNemar’s tests were both statistically non-significant (p = 0.4142 and p = 0.3173); thus, we cannot reject that the distributions of the reassessments were equal between the first and second reassessment. The weighted kappa values of the life-threatening danger assessment severity for assessor 1 and assessor 2 were 0.90 (95% CI, 0.82 to 0.97), p < 0.0001, and 0.94 (95% CI, 0.89 to 0.99), respectively. According to McHugh, the latter is interpreted as an almost perfect level of agreement. Bowker’s tests of symmetry were both not statistically significant (p = 0.2839 and p = 0.5724), so we cannot reject that the assessors had the same propensity to assess the degree of severity during the first and second time of reassessment (see Table 3).
Research question 2: Did the new protocol influence the severity of the life-threatening danger assessments compared to the former practice?
Of the 262 included cases in the 2-year period, 201 had sharp force injuries, and 60 had gunshot wounds. There was one case with both documented sharp force injuries and gunshot wounds, as the second case with injury co-occurrence was from before September 13, 2015. The median age for the 53 included females was 23 years (15–76 years) and for the 209 included males 26 years (15–82 years). The life-threatening danger assessment was undetermined (U) in two cases, and five individuals died (D) before the forensic report was sent to the police. In total, 217 cases had a life-threatening danger assessment, and the proportion of these cases with registered hospital record and/or verbal communication increased from 89 to 93%. After the implementation, the number of clinical-underlying argumentations shows a statistically significant increase from 36 to 110 (chi-square = 18.92; p < 0.0001), whereas tort- and literary-underlying argumentations decreased from 47 to zero and from four to two, respectively. The year after implementation, 83% of the cases without an underlying danger assessment argument were NLD cases.
Original life-threatening danger assessments 1 year before and after the protocol implementation
Table 4 shows the number of cases with or without a life-threatening danger assessment the year before and after the implementation date of September 13, 2016. The proportion of NA cases was 13% the year before and 16% the year after the implementation. The PLD and MLD conclusions did not appear after the implementation. The proportion of cases with an NLD assessment increased from 9 to 43%. Conversely, the proportion of cases with a PLD or CLD assessment decreased from 55 to 23%. The proportion of cases with an MLD or LD assessment decreased from 20 to 17%. A Fisher’s exact test was performed between the life-threatening danger assessments made the year before and after the protocol implementation (Table 5) because some of the assessments had under five expected observations. A statistically significant redistribution was observed for the life-threatening danger assessments the year after implementation compared to the danger assessment distribution the year prior to implementation (chi-square = 44.96; p < 0.0001), and the NLD and PLD + CLD conclusions contributed the most (see cell chi-square values in Table 5).
Comparison of the original life-threatening danger assessments and reassessment severity
Table 6 compares the original life-threatening danger assessments with the reassessments made by the assessors in order to answer research question 1. Assessor 1 stated that assessment of the life-threatening danger of the documented injuries was not possible (NP) or not relevant (NR) in 41% of the original NA cases. That percentage was 32% for assessor 2. In 47% and 53% of the NA cases, assessors 1 and 2, respectively, assessed the case as NLD. Both assessors reassessed some of the NA cases as LD, 12% for assessor 1 and 15% for assessor 2. Of the original PLD + CLD cases, 28% (assessor 1) and 23% (assessor 2) were reassessed as CLD, whereas 55% of them resulted in an NLD assessment, and 7% (assessor 1) and 16% (assessor 2) in a LD assessment. The original MLD + LD cases were reassessed as LD in 83% and 100% of the cases by assessors 1 and 2, respectively. Assessor 1 reassessed the rest of the MLD cases as CLD (17%).
Discussion
Statements of principal findings
Our first main finding, based on our results, was that the protocol needs criteria for when it should be used. However, when the board-certified forensic specialists decided to make a life-threatening danger assessment, the severity of the danger assessments were inter-rater independent and reproducible. The McNemar’s test indicated that the evidence is insufficient to conclude that no agreement exists between assessors 1 and 2 (p = 0.2008), but the level of agreement on whether to make a life-threatening danger assessment was weak, with a Cohen’s kappa coefficient of 0.43. By contrast, the inter-rater severity, with a weighted kappa coefficient of 0.87 (95% CI, 0.82 to 0.93), can be interpreted as a strong level of agreement [21], despite a Bowker’s test of symmetry that was statistically significant (p = 0.0062), which means that the assessors did not have the same propensity to assess the severity of the injuries. The latter is consistent with the findings in Table 2, where assessor 1 had far more CLDs than assessor 2, and assessor 2 generally assessed the life-threatening danger as more severe than assessor 1. The same patterns regarding the degree of agreement were seen for assessor 1’s intra-rater agreement analyses (yes/no danger assessment, Κ = 0.57; and danger assessment’s severity, Κ = 0.90), whereas both of assessor 2’s kappa coefficients indicated a strong (yes/no danger assessment) and almost perfect (severity) degree of intra-rater agreement [21]. For both assessors, the tests regarding symmetry were not statistically significant (i.e., the evidence was insufficient to reject agreement and they both had the same propensities to assess the severity of the injuries).
Our second main finding was that the life-threatening danger assessments became less severe when the two board-certified forensic specialists reassessed prior-protocol cases. PLD and MLD did not appear after the protocol implementation, which indicates that the forensic specialists immediately adopted the new protocol. The increase in NLDs and the assessors’ reassessments of NA cases as NLD (47% and 53%, respectively) could indicate an increased post-protocol active mentioning of nonlife-threatening danger instead of a prior-protocol passive omission in cases where the examined victims were assessed as having not been in life-threatening danger. However, no increase was noted in the proportion of cases with a life-threatening danger assessment after the protocol implementation (82%) compared to the former practice (84%). Instead, the life-threatening danger assessments statistically significantly changed from PLD + CLD to NLD. The latter was also indicated by the assessors’ reassessments of prior-protocol cases that resulted in a severity decrease, as 55% of the prior-protocol PLD + CLD cases were reassessed as NLDs. The results indicate that most prior-protocol cases with a PLD + CLD conclusion would have been assessed as NLD had the protocol implementation happened earlier. This most likely is a result of the protocol’s outlined, clinical-underlying criteria and the resulting increase in clinical-underlying argumentation, as well as the exclusion of the hypothetical outcome of the violent act (i.e., the tort-underlying argumentation).
Both assessors reassessed prior-protocol NA cases as LD, which may indicate that some of the cases should have had a life-threatening danger assessment. In 57% of assessor 1’s and 31% of assessor 2’s NPs, they stated that it was not possible to reassess the life-threatening danger despite an available hospital record (data not shown). The CFM database’s lack of specification of “hospital record” (e.g., emergency records, ward round records, or operative notes) may explain their decision not to reassess the case as; in multiple cases, they stated that they specifically lacked an operation description. A future recommendation could be to specify what information should be available.
Strength and limitations of this study
Random selection of sharp force injury cases for the reassessments should prevent selection bias in terms of case circumstances and the information upon which the life-threatening danger assessment was based (e.g., information of vital parameters, age, co-occurrence of injury types). Thus, they are a representative sample of cases with documented sharp force injuries. Blinding the original life-threatening danger assessments, the unknown distribution of them and the random selection of the cases for the batches ensured that the assessors could not predict the original assessments. Moreover, the 2-month interval between the first and second reassessments and the random selection of cases for the intra-observer agreement analyses ensured minimized recall bias. Lastly, it could be argued that the type of penetrating injury may have influenced the assessors as one could speculate that gunshot wounds were assessed more seriously than sharp force injuries. However, the protocol’s highlighted criteria comprise both types of penetrating injuries and should ensure that only the prior-to-treatment anatomical injuries and subsequent health state form the basis of the life-threatening danger assessment, not the type of injury.
The use of the Fleiss-Cohen quadratic weights [16] for the weighted kappa analyses resulted in a graduation of the disagreements, where the penalties for disagreement become severer as the disagreements become larger [17]. We consider this to be the most appropriate approach regarding the assessments of life-threatening danger severity.
The reassessments may not be representative for all the department’s board-certified forensic specialists who use the protocol due to the nonrandom selection of the assessors, who have special clinical forensic responsibilities. Moreover, the selected cases with penetrating injuries represent only one-third of the protocol, and our conclusions regarding the usability of the protocol are therefore restricted to cases with documented sharp force injuries and/or gunshot wounds.
We consider the inclusion of all forensic victim examinations in the 2-year period as a strength, but the selection of the year up to and just after the implementation may not be representative for the implementation effect in the longer term. We do not know whether an intensified focus on the new protocol occurred during the selected time interval. To consider this, we could have chosen, for example, the years 2013 and 2019.
The protocol is part of the department’s DANAK-accredited regulatory tasks [4, 22, 23] and is regularly updated. However, despite moving from individual expert opinions to a standardized approach and consistent terminology, the forensic life-threatening danger assessments lack evidence-based validation.
Conclusion
Our results suggest that the protocol is inter-observer independent and reproducible when the board-certified forensic specialists agreed that a life-threatening danger assessment should be made. However, the results also suggest that the protocol must include and specify criteria for when it should be used. The protocol implementation did not result in an increased number of life-threatening danger assessments, but the changed terminology and the disappearance of the tort-underlying argumentation are indications of successful protocol implementation. Using the implemented protocol on prior-protocol cases made the life-threatening danger assessment less severe, as the number of post-protocol NLD cases increased and the majority of the prior-protocol, tort-argued PLD + CLD cases were reassessed as NLD by the board-certified forensic specialists.
Perspective
The results raise some very important questions: How can we know that the new protocol is better than the former practice, and what impact do the changed forensic life-threatening danger assessments have on the legal aftermath? Evidence-based CFM is challenging, as it is not possible to perform randomized clinical trials, which is the pinnacle of the evidence hierarchy [10, 24, 25]. Despite the fact that the tort-underlying argumentation was replaced by the clinical-underlying argumentation, the evidence behind the implemented protocol is unknown. Thus, the protocol cannot be characterized as an evidence-based guideline. Therefore, future studies should examine the reliability of the protocol and its clinical-underlying argumentation, as well as the impact of forensic life-threatening danger assessments on the legal aftermath and the potential consequences of the documented severity decrease.
Data availability
Not applicable.
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Acknowledgments
The researchers would like to thank the Section of Forensic Pathology’s Computer Security Officer Peter Kastmand Larsen for technical assistance. We also wish to thank the Danish Victims Fund for financial support for the research.
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The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: These materials have received financial support from the Danish Victims Fund (grant number 15-910-00024). The authors are responsible of the execution, content, and results of the materials.
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Lykke Schrøder Jakobsen, Niels Lynnerup, and Jytte Banner contributed to the study conception and design. All the authors performed material preparation, data collection, and analysis. The first draft of the manuscript was written by Lykke Schrøder Jakobsen, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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The CFM database was approved by The Danish Data Protection Agency (SUND-2017-70) and belongs to the Department of Forensic Medicine; thus, data is not publicly available.
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Jakobsen, L.S., Christensen, M.T., Lundemose, S.B. et al. Life-threatening danger assessments of penetrating injuries in Eastern Danish clinical forensic medicine. Int J Legal Med 135, 861–870 (2021). https://doi.org/10.1007/s00414-020-02485-9
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DOI: https://doi.org/10.1007/s00414-020-02485-9