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Preface 2012
We deeply appreciate the great contributions of many physicians in the registry of esophageal cancer cases. The Comprehensive Registry of Esophageal Cancer in Japan, 2012, was published here, despite some delay. The registry complies with the Act for the Protection of Personal Information. The encryption with a HASH function is used for anonymity in an unlinkable fashion.
We briefly summarized the Comprehensive Registry of Esophageal Cancer in Japan, 2012. Japanese Classification of Esophageal Cancer 10th [1] and UICC TNM Classification 7th [2] were used for cancer staging according to the subjected year. A total of 8003 cases were registered from 316 institutions in Japan. Tumor locations were cervical: 4.6%, upper thoracic: 12.8%, middle thoracic: 47.9%, lower thoracic: 26.1% and EG junction: 7.6%. Superficial carcinomas (Tis, T1a, T1b) were 38.2%. As for the histologic type of biopsy specimens, squamous cell carcinoma and adenocarcinoma accounted for 89.5% and 6.0%, respectively. Regarding clinical results, the 5-year survival rates of patients treated using endoscopic resection, concurrent chemoradiotherapy, radiotherapy alone, or esophagectomy were 84.4, 32.4, 24.9, and 55.6%, respectively. The endoscopic submucosal dissection accounted for 84.9% of endoscopic resection. Esophagectomy was performed in 4722 cases. Concerning the approach used for esophagectomy, 36.0% of the cases were treated thoracoscopically. The operative mortality (within 30 days after surgery) was 0.52% and the hospital mortality was 2.35%. The 5-year survival rate of patients with pStage IV in UICC classification (including patients with supraclavicular node metastasis) was better than that of patients with pStage IVb in JES classification (not including patients with supraclavicular node metastasis).
We hope that this Comprehensive Registry of Esophageal Cancer in Japan for 2012 will help to improve all aspects of the diagnosis and treatment of esophageal cancer in Japan.
Contents
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I.
Clinical factors of esophageal cancer patients treated in 2012
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1.
Institution-registered cases in 2012
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2.
Patient background
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Table 1 Age and gender
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Table 2 Primary treatment
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Table 3 Tumor location
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Table 4 Histologic types of biopsy specimens
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Table 5 Depth of tumor invasion, cT (UICC TNM 7th)
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Table 6 Lymph node metastasis, cN (UICC TNM 7th)
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Table 7 Distant metastasis, cM (UICC TNM 7th)
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Table 8 Clinical stage (UICC TNM 7th)
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1.
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II.
Results of endoscopically treated patients in 2012
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Table 9 Details of endoscopic treatment for curative intent
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Table 10 Complications of EMR/ESD
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Table 11 Pathological depth of tumor invasion of EMR/ESD specimens
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Figure 1 Survival of patients treated with EMR/ESD
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Figure 2 Survival of patients treated with EMR/ESD according to the pathological depth of tumor invasion, pT (UICC TNM 7th)
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Figure 3 Survival of patients treated with EMR/ESD according to the lymphatic and venous invasion
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III.
Results in patients treated with chemotherapy and/or radiotherapy in 2012
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Table 12 Dose of irradiation (non-surgically treated cases)
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Table 13 Dose of irradiation (surgically treated cases)
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Figure 4 Survival of patients treated with chemotherapy and/or radiotherapy
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Figure 5 Survival of patients treated with definitive chemoradiotherapy according to clinical stage (UICC TNM 7th)
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Figure 6 Survival of patients underwent radiotherapy alone according to clinical stage (UICC TNM 7th)
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IV.
Results in patients who underwent esophagectomy in 2012
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Table 14 Treatment modalities of esophagectomy
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Table 15 Tumor location
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Table 16 Approaches to tumor resection
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Table 17 Video-assisted surgery
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Table 18 Fields of lymph node dissection according to the location of the tumor
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Table 19 Reconstruction route
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Table 20 Organs used for reconstruction
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Table 21 Histological classification
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Table 22 Depth of tumor invasion, pT (JES 10th)
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Table 23 Pathological grading of lymph node metastasis, pN (JES 10th)
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Table 24 Pathological findings of lymph node metastasis, pN (UICC 7th)
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Table 25 Pathological findings of distant organ metastasis, pM (JES 10th)
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Table 26 Residual tumor
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Table 27 Causes of death
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Figure 7 Survival of patients who underwent esophagectomy
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Figure 8 Survival of patients who underwent esophagectomy according to clinical stage (JES 10th)
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Figure 9 Survival of patients who underwent esophagectomy according to clinical stage (UICC 7th)
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Figure 10 Survival of patients who underwent esophagectomy according to the depth of tumor invasion, pT (JES 10th)
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Figure 11 Survival of patients who underwent esophagectomy according to lymph node metastasis, pN (JES 10th)
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Figure 12 Survival of patients who underwent esophagectomy according to lymph node metastasis, pN (UICC 7th)
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Figure 13 Survival of patients who underwent esophagectomy according to pathological stage (JES 10th)
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Figure 14 Survival of patients who underwent esophagectomy according to pathological stage (UICC TNM 7th)
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Figure 15 Survival of patients who underwent esophagectomy according to residual tumor (R)
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I. Clinical factors of esophageal cancer patients treated in 2012
Institution-registered cases in 2012
Institution |
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Ageo Central General Hospital |
Aichi Cancer Center |
Aichi Medical University Hospital |
Aizawa Hospital |
Akaishi Hospital |
Akita Kouseiren Hiraga Hospital |
Akita University Hospital |
Aomori City Hospital |
Arao Municipal Hospital |
Asahikawa Medical College Hospital |
Cancer Institute Hospital of JFCR |
Chiba Cancer Center |
Chiba Medical Center |
Chiba University Hospital |
Chibaken Saiseikai Narashino Hospital |
Chigasaki Municipal Hospital |
Dokkyo Medical University Hospital |
Dokkyo Medical University Saitama Medical Center |
Ehime University Hospital |
Eiju General Hospital |
Foundation for Detection of Early Gastric Carcinoma |
Fuchu Hospital |
Fujioka General Hospital |
Fujisawa Shounandai Hospital |
Fujita Health University Hospital |
Fukui Prefectural Hospital |
Fukui University Hospital |
Fukui-ken Saiseikai Hospital |
Fukuoka Dental College and Dental Hospital |
Fukuoka Saiseikai General Hospital |
Fukuoka University Chikushi Hospital |
Fukuoka University Hospital |
Fukuoka Wajiro Hospital |
Fukushima Medical University Hospital |
Fukuyama City Hospital |
Fussa Hospital |
Gifu Prefectural General Medical Center |
Gifu University Hospital |
Gunma Central General Hospital |
Gunma Prefectural Cancer Center |
Gunma University Hospital |
Gunmaken Saiseikai Maebashi Hospital |
Hachinohe City Hospital |
Hakodate Goryokaku Hospital |
Hakodate National Hospital |
Hamamatsu University School of Medicine, University Hospital |
Heartlife Hospital |
Higashiosaka City Medical Center |
Hino Memorial Hospital |
Hino Municipal Hospital |
Hiratsuka City Hospital |
Hiratsuka Kyosai Hospital |
Hirosaki University Hospital |
Hiroshima City Asa Hospital |
Hiroshima City Hiroshima Citizens Hospital |
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital |
Hiroshima University Hospital |
Hitachi General Hospital |
Hokkaido University Hospital |
Hyogo Cancer Center |
Hyogo Prefectural Nishinomiya Hospital |
Ibaraki Prefectural Central Hospital |
Iizuka Hospital |
Imazu Surgical Clinic |
Inazawa City Hospital |
International University of Health and Welfare Hospital |
International Goodwill Hospital |
International University of Health and Welfare Mita Hospital |
Isehara Kyodo Hospital |
Ishikawa Prefectural Central Hospital |
Iwate Medical University Hospital |
Iwate Prefectural Central Hospital |
Iwate Prefectural Chubu Hospital |
Iwate Prefectural Isawa Hospital |
Japanese Red Cross Fukui Hospital |
Japanese Red Cross Ishinomaki Hospital |
Japanese Red Cross Kyoto Daini Hospital |
Japanese Red Cross Nagaoka Hospital |
Japanese Red Cross Okayama Hospital |
Japanese Red Cross Society Kyoto Daiichi Hospital |
Japanese Red Cross Tottori Hospital |
JCHO Kurume General Hospital |
JCHO Kyushu Hospital |
JCHO Miyazaki Konan Hospital |
JCHO Osaka Hospital |
JCHO Saitama Medical Center |
JCHO Tokuyama Central Hospital |
JCHO Yokohama Chuo Hospital |
Jichi Medical University Hospital |
Jichi Medical University Saitama Medical Center |
Juntendo University Hospital |
Juntendo University Shizuoka Hospital |
Junwakai Memorial Hospital |
Kagawa Prefectural Central Hospital |
Kagawa Rosai Hospital |
Kagawa University Hospital |
Kagoshima Kenritsu Satsunan Hospital |
Kagoshima University Hospital |
Kaizuka City Hospital |
Kameda General Hospital |
Kanagawa Cancer Center |
Kanazawa University Hospital |
Kansai Medical University Hospital |
Kansai Medical University Medical Center |
Kansai Rosai Hospital |
Kasamatsu Hospital |
Kashiwa Kousei General Hospital |
Kawakita General Hospital |
Kawasaki Medical School Hospital |
Kawasaki Medical School Kawasaki Hospital |
Kawasaki Municipal Ida Hospital |
Keio University Hospital |
Keiyukai Sapporo Hospital |
Kikuna Memorial Hospital |
Kin-ikyo Chuo Hospital |
Kinki Central Hospital |
Kinki University Hospital |
Kiryu Kosei General Hospital |
Kishiwada City Hospital |
Kitaakita Municipal Hospital |
Kitakyushu Municipal Medical Center |
Kitano Hospital |
Kitasato Institute Hospital |
Kitasato University Hospital |
Kobe City Medical Center General Hospital |
Kobe City Nishi-Kobe Medical Center |
Kobe University Hospital |
Kochi Health Sciences Center |
Kochi University Hospital |
Kokura Memorial Hospital |
Kumagaya General Hospital |
Kumamoto City Hospital |
Kumamoto University Hospital |
Kurashiki Central Hospital |
Kurume University Hospital |
Kusatsu General Hospital |
Kyorin University Hospital |
Kyoto University Hospital |
Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers |
Kyushu Medical Center |
Kyushu University Beppu Hospital |
Kyushu University Hospital |
Machida Municipal Hospital |
Matsuda Hospital |
Matsudo City Hospital |
Matsushita Memorial Hospital |
Matsuyama Red Cross Hospital |
Mie University Hospital |
Minamiosaka Hospital |
Minamiyamato Hospital |
Mino City Hospital |
Mito Red Cross Hospital |
Mitsui Memorial Hospital |
Moriguchi Keijinkai Hospital |
Murakami General Hospital |
Musashino Red Cross Hospital |
Nagahama City Hospital |
Nagano Red Cross Hospital |
Nagaoka Chuo General Hospital |
Nagasaki University Hospital |
Nagoya City East Medical Center |
Nagoya City University Hospital |
Nagoya City West Medical Center |
Nagoya Daiichi Red Cross Hospital |
Nagoya University Hospital |
Nanpuh Hospital |
Nara City Hospital |
Nara Medical University Hospital |
National Cancer Center Hospital |
National Cancer Center Hospital East |
National Defense Medical College Hospital |
National Institute of Radiological Sciences Hospital |
Nerima Hikarigaoka Hospital |
NHO Beppu Medical Center |
NHO Chiba Medical Center |
NHO Chiba-East-Hospital |
NHO Fukuoka-higashi Medical Center |
NHO Himeji Medical Center |
NHO Hokkaido Cancer Center |
NHO Kanmon Medical Center |
NHO Kure Medical Center |
NHO Kyoto Medical Center |
NHO Kyushu Cancer Center |
NHO Matsumoto Medical Center |
NHO Nagasaki Medical Center. |
NHO Nagoya Medical Center |
NHO Okayama Medical Center |
NHO Osaka National Hospital |
NHO Tokyo Medical Center |
Nihonkai General Hospital |
Niigata Cancer Center Hospital |
Niigata City General Hospital |
Niigata Prefectural Shibata Hospital |
Niigata University Medical and Dental Hospital |
Nikko Memorial Hospital |
Nippon Medical School Chiba Hokusoh Hospital |
Nippon Medical School Hospital |
Nippon Medical School Musashi Kosugi Hospital |
Nippon Medical School Tama Nagayama Hospital |
Nishinomiya Municipal Central Hospital |
NTT Medical Center Tokyo |
NTT WEST Osaka Hospital |
Numazu City Hospital |
Obihiro Kousei Hospital |
Ogachi Central Hospital |
Ogaki Municipal Hospital |
Ohta Nishinouchi Hospital |
Oita Red Cross Hospital |
Oita University Hospital |
Okayama Saiseikai General Hospital |
Okayama University Hospital |
Omuta Tenryo Hospital |
Osaka City General Hospital |
Osaka City University Hospital |
Osaka Ekisaikai Hospital |
Osaka General Medical Center |
Osaka International Cancer Institute |
Osaka Medical College Hospital |
Osaka Police Hospital |
Osaka Red Cross Hospital |
Osaka University Hospital |
Otsu City Hospital |
Rinku General Medical Center |
Ryukyu University Hospital |
Saga University Hospital |
Saga-ken Medical Center Koseikan |
Saiseikai Fukushima General Hospital |
Saiseikai Kyoto Hospital |
Saiseikai Utsunomiya Hospital |
Saiseikai Yahata General Hospital |
Saiseikai Yokohamashi Tobu Hospital |
Saitama Cancer Center |
Saitama City Hospital |
Saitama Medical University Hospital |
Saitama Medical University International Medical Center |
Saitama Medical University Saitama Medical Center |
Sakai City Medical Center |
Saku Central Hospital |
Sanin Rosai Hospital |
Sendai City Hospital |
Sendai Medical Center |
Shiga General Hospital |
Shiga University of Medical Science Hospital |
Shikoku Cancer Center |
Shimane University Hospital |
Shimizu Welfare Hospital |
Shinko Hospital |
Shizuoka Cancer Center |
Shizuoka City Shizuoka Hospital |
Shizuoka General Hospital |
Showa University Hospital |
Showa University Koto-Toyosu Hospital |
Sonoda Daiichi Hospital |
Southern Tohoku General Hospital |
St. Luke’s International Hospital |
St. Marianna University School of Medical Hospital |
Steel Memorial Hirohata Hospital |
Sugita Genpaku Memorial Obama Municipal Hospital |
Suita Municipal Hospital |
Tachikawa Hospital |
Takasago Municipal Hospital |
Teikyo University Chiba Medical Center |
Teikyo University Hospital |
Teine Keijinkai Hospital |
Tenri Hospital |
The Jikei University Daisan Hospital |
The Jikei University Hospital |
Tochigi Cancer Center |
Toho University Ohashi Medical Center |
Toho University Omori Medical Center |
Toho University Sakura Medical Center |
Tohoku University Hospital |
Tokai University Hachioji Hospital |
Tokai University Hospital |
Tokai University Tokyo Hospital |
Tokushima Red Cross Hospital |
Tokushima University Hospital |
Tokyo Dental College Ichikawa General Hospital |
Tokyo Medical and Dental University Hospital |
Tokyo Medical University Hachioji Medical Center |
Tokyo Medical University Hospital |
Tokyo Medical University Ibaraki Medical Center |
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital |
Tokyo Metropolitan Tama Medical Center |
Tokyo Saiseikai Central Hospital |
Tokyo University Hospital |
Tokyo Women’s Medical University Hospital |
Tokyo Women’s Medical University Medical Center East |
Tokyo Women’s Medical University Yachiyo Medical Center |
Tonan Hospital |
Toranomon Hospital |
Toshima Hospital |
Tottori Prefectural Central Hospital |
Tottori University Hospital |
Toyama Prefectural Central Hospital |
Toyama University Hospital |
Toyonaka Municipal Hospital |
Tsuchiura Kyodo Hospital |
Tsukuba University Hospital |
Tsuruoka Municipal Shonai Hospital |
University Hospital, Kyoto Prefectural University of Medicine |
University of Miyazaki Hospital |
Urasoe General Hospital |
Wakayama Medical University Hospital |
Yamagata Prefectural Central Hospital |
Yamagata Prefectural Shinjo Hospital |
Yamagata University Hospital |
Yamaguchi University Hospital |
Yamaguchi-ken Saiseikai Shimonoseki General Hospital |
Yamanashi Prefectural Central Hospital |
Yamanashi University Hospital |
Yao Municipal Hospital |
Yokohama City Municipal Hospital |
Yokohama City University Medical Center |
Yokohama Rosai Hospital |
Yuri Kumiai General Hospital |
Patient Background
Tables 1, 2, 3, 4, 5, 6, 7, 8.
II. Results of endoscopically treated patients in 2012
Tables 9, 10, 11 and Figs. 1, 2, 3.
III. Results in patients treated with chemotherapy and/or radiotherapy in 2012
Tables 12, 13 and Figs. 4, 5, 6.
IV. Results in patients who underwent esophagectomy in 2012
Tables 14,15,16,17,18,19,20,21,2223,24,25,26,27, and Figs. 7, 8, 9, 10, 11, 12, 13, 14, 15.
References
Japan Esophageal Society. Japanese classification of esophageal cancer, 10th edition: part I. Esophagus. 2009;6:1–25.
Sobin LH, Gospodarowicz MK, Wittekind C. UICC International Union Against Cancer. TNM classification of malignant tumors. 7th ed. New York: Wiley-Blackwell; 2009.
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Ethical Statement
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.
Informed consent
Informed consent or substitute for it was obtained from all patients for being included in the study.
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All authors have nothing to disclose with regard to commercial support.
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These data were first made available on March 2019, as the Comprehensive Registry of Esophageal Cancer in Japan, 2012.
The authors were members of the Registration Committee for Esophageal Cancer, the Japan Esophageal Society, and made great contributions to the preparation of this material.
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Tachimori, Y., Ozawa, S., Numasaki, H. et al. Comprehensive registry of esophageal cancer in Japan, 2012. Esophagus 16, 221–245 (2019). https://doi.org/10.1007/s10388-019-00674-z
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DOI: https://doi.org/10.1007/s10388-019-00674-z