Abstract
Background
Obesity affects 1.5 billion people worldwide, yet few are treated effectively and considerable variability exists in its management. In 2020, a joint International Federation of Surgery for Obesity and Metabolic Diseases (IFSO) and World Gastroenterology Organization (WGO) advisory committee initiated the drafting of consensus guidelines on obesity management, to be based on detailed literature reviews and the results of an extensive multi-disciplinary survey of intercontinental experts. This paper reports on the latter. The objective of this study is to identify areas of consensus and non-consensus among intercontinental, inter-disciplinary experts in obesity management.
Methods
Guided by an international consensus-survey expert, a three-round online Delphi survey was conducted in the summer of 2021 of international obesity-management experts spanning the fields of medicine, bariatric endoscopy and surgery, psychology, and nutrition. Issues like epidemiology and risk factors, patient selection for metabolic and bariatric surgery (ASMBS-Clinical-Issues-Committee, Surg Obes Relat Dis : Off J Am Soc Bariatric Surg. 8:e27-32, 1), psychological issues, patient preparation for MBS, bariatric endoscopy, and outcomes and follow-up were addressed.
Results
Ninety-four experts from six continents voted on 180 statements, with consensus reached on 158, including consensus agreement with 96 and disagreement with 24 statements (38 had other response options besides agree/disagree). Among unanimous opinions were the need for all medical societies to work together to address obesity, for regular regional and national obesity surveillance, for multi-disciplinary management, to recognize the increasing impact of childhood and adolescent obesity, to accept some weight regain as normal after MBS, and for life-long follow-up of MBS patients.
Conclusions
Obesity is a major health issue that requires aggressive surveillance and thoughtful multidisciplinary management.
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Introduction
Approximately 1.5 billion people worldwide currently live with obesity [1], and this number is rising [2,3,4], even among children and adolescents [5]. Beyond its own implications for health and fitness, obesity increases the risk of numerous other potentially life-threatening complications, like type 2 diabetes mellitus (T2DM) [6], cardiovascular disease [7], and at least 13 distinct types of cancer [8, 9]. Excess weight has also been linked to significantly decreased quality of life (QoL) [2], significantly increased risk of early mortality, decreased life expectancy [10], and increased cancer-related mortality [11]. These risks even extend to childhood obesity [12].
Managing obesity is difficult, with “eating less and exercising more” rarely attaining long-term success. Consequently, and because of the numerous obesity-associated comorbidities, obesity has been termed “a chronic relapsing progressive disease” [13]. While dietary changes, other lifestyle changes like exercise, and counselling remain the first line of treatment, relatively recent advances in obesity management have included pharmacological, endoscopic, and surgical interventions. Metabolic and bariatric surgery (MBS) remains significantly more effective than dietary and lifestyle changes alone at inducing weight loss, reducing comorbidities, and improving QoL [14,15,16,17].
Several operative interventions currently exist and which procedure is chosen and when to offer surgery varies between practices and regions [18]. Bariatric procedures also carry their own risks, including a low, but non-negligible (0.15–0.35%) risk of peri-operative mortality [19, 20]. Additional complications of MBS include potentially fatal nutritional deficiencies [21,22,23,24]; post-operative bleeding, intestinal obstructions, severe gastroesophageal reflux, and various gastrointestinal syndromes [19]. Patients undergoing MBS may also be prone to developing new post-operative addictive behaviours like substance abuse [25]. Consequently, MBS should not be used to replace, but to supplement other, non-operative approaches to obesity management, including dietary and lifestyle changes. It is also important to identify and treat psychopathology, utilizing psychosocial counselling and pharmacotherapy [25]. However, like choosing operative procedures, variability exists in how and to what extent such services are co-administered [26]. Variability also exists in which patients are considered eligible and safe for endoscopic and bariatric procedures [27]; how to define treatment success and failure [16, 28]; how much weight regain should be considered acceptable [29]; and which metric to utilize for measuring weight regain (e.g., as a percentage of excess vs. total weight) [30].
It was such variability and uncertainty that led the World Gastroenterology Organization (WGO) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) to join forces in 2020 to take steps towards drafting international guidelines on the management and long-term monitoring of obesity. This included undertaking a survey of 94 international, interdisciplinary experts in obesity management to identify areas of consensus and non-consensus spanning a range of topics. This paper reports those results.
Methods
An online modified Delphi survey was conducted following published guidelines [31]. The Delphi approach was adopted because of its exponentiallyincreasing utilization in health science and other fields and its unanimous voting, thereby reducing the risk of conformity/acquiescence bias typically ascribed to in-person consensus meetings [31].
Survey development with each steering committee member generating a list of issues/questions of major interest within their own discipline. To be considered for survey inclusion, the issue could not already be considered a firmly established, universal standard of care based upon published empirical evidence, but had to be considered of appreciable importance to obesity management. Issues of interest ranged from epidemiology and public perceptions to treatment and follow-up.
All submitted statements were sent to the steering committee for statement selection; then to the Delphi expert for editing, consolidation into a single survey, and reformatting to ensure comprehensibility and consistency. Several steps were undertaken to reduce any risk of bias potentially induced by the survey itself, including primarily using non-judgmental statements (e.g., neither favouring nor opposing a particular concept/belief/approach); balancing the remaining favourable and unfavorable statements; and altering the order of response options to minimize order bias (e.g., favorable options listed anywhere from first to last). The survey’s first full draft was sent to all steering-committee members for feedback and potential modification, after which a pilot survey of 10 experts was conducted to identify all language, factual, or conceptual issues.
The final Round 1 survey had 157 statements subdivided into six modules: Module 1: Epidemiology and risk factors (20 statements); Module 2: Patient selection for MBS (29 statements); Module 3: Psychological issues (14 statements); Module 4: Patient preparation for MBS (23 statements); Module 5: Bariatric endoscopy (39 statements, only voted on by surgeons and endoscopists); and Module 6: Outcomes and follow-up (32 statements). Statements failing to achieve ≥ 70% consensus were included in a second-round survey. Each expert was asked at both the start and end of each module how comfortable they felt voting on that module’s focus, rated from very uncomfortable to very comfortable so votes from uncomfortable voters could be excluded during data analysis. At least 80% participation of eligible voters on any statement was required for that statement’s vote tally to be considered valid.
In June 2021, an email was sent to 100 experts who had previously agreed to participate in the survey, including a link to the above-mentioned, committee-approved Round 1 survey on the online platform Survey Monkey. Practice characteristics of the 94 who ultimately participated, and of the n = 37 bariatric surgeons and n = 55 with experience in bariatric endoscopy are summarized in Table 1.
Results
Among the five modules open to all experts, voter numbers ranged from 80 to 94 (85–100%) out of 94; for Module 5, restricted to 58 bariatric surgeons and/or endoscopists, voter numbers ranged from 54 to 58 (94.7–100%). Hence, a valid vote was achieved for every statement.
After Round 1 results were analyzed, 23 statements on the “relative importance of pre-operative patient factors” were added to the Round 2 survey. Final analysis was, therefore, of 180 (157 + 23) statements.
Among the 180 statements included in final analysis, only 17 (9.4%) were deemed by the advisory panel as favorable to a particular concept/belief/approach, 19 unfavorable (10.6%), and 144 (80.0%) non-judgmental (Table 2). An abbreviated third round of voting was conducted for the eight of 23 statements added to Round 2 for which no consensus was achieved in that round, thereby permitting two rounds of voting on all statements requiring a second vote.
At least 70% consensus was achieved on 158 statements (87.8%)—114 first round, 44 s round. However, 100% consensus was only achieved for 12 statements. Table 2 provides further general results.
The results for each of the six modules are summarized individually in Tables 3, 4, 5, 6, 7, 8, and 9, with Module 2 subdivided into part A (Table 4) and part B (Table 5).
On epidemiology and risk factors, unanimous consensus was reached that all medical societies must address obesity systematically and that regular longitudinal national and regional surveillance is necessary. Strong consensus was achieved defining obesity as a chronic disease that increases both morbidity and mortality risks; that emotional eating is a common feature but also that eating binges not universal among those with obesity; and that ethnicity and geographical factors are important, both pathophysiologically and when considering interventions. Experts agreed that food addiction is a valid clinical entity, and common among patients undergoing MBS, especially those with problematic alcohol and/or drug use; but were split on whether food addiction affects a great majority of patients considering MBS. They also agreed that binge eating is a risk factor for weight regain after MBS, but disagreed it is a risk factor for suicidal ideations/attempts. All Module 1 results are summarized in Table 3.
On patient selection (Table 4), there was 100% consensus that global rates of obesity are increasing in children and adolescents; that obesity during childhood or adolescence portends obesity in adulthood; that severe obesity in the young portends significant obesity-related co-morbidity, like diabetes and hypertension; that MBS in youths requires a multi-disciplinary team with experience dealing with youths and their families; and that inadequate public and physician knowledge and scarce long-term results of MBS in youths are barriers to MBS use in youths. There also was near-unanimous agreement that life-long monitoring is necessary for youths who undergo MBS and that MBS in youths should be performed by experienced bariatric surgeons with a proven track record of success in adults. Experts agreed that enough empirical evidence has been published supporting MBS as the most effective therapy for severe obesity in youths and that MBS outcomes in youths are similar to those achieved in adults. However, certain MBS procedures, like biliopancreatic diversion (BD) and one-anastomosis gastric bypass (OAGB), were not recommended for youths.
Considering seniors, there again was consensus that MBS is generally effective and safe and increases QoL and that age should not be the only consideration when deciding on surgery. Conversely, there was consensus that operating time is directly predictive of negative outcomes in seniors, and that seniors’ risks from MBS are greater than adolescents. No consensus was reached concerning on the age when operative candidates should be considered elderly, on outcomes post-Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG) relative to outcomes in adolescents, or on the gold standard MBS procedure for seniors. Table 5 ranks 23 pre-operative factors by their relative level of importance, with all but financial means and thyroid disease considered very important by ≥ 70% of our experts.
Among psychological issues, there was consensus disagreement that patients undergoing MBS always develop problematic alcohol use or mostly experience worsened depression post-operatively. Experts also disagreed that those patients with pre-MBS cognitive depressive symptoms usually do not improve post-operatively, as opposed to those who have meaningful post-operative weight loss and usually experience improvement in their depression post MBS. However, there also was consensus agreement that suicide is more common in patients who have undergone MBS. Strong consensus was reached that a comprehensive psychological evaluation is necessary pre-operatively, and that even patients with severe psychiatric illness can undergo MBS if it is well controlled. Experts also agreed that patients with food addiction are more likely to have other psychiatric conditions—like depression and anxiety—than those without, and that cognitive behavioral therapy is the best therapeutic strategy for patients at high risk of binge eating. Further results on psychological issues are summarized in Table 6.
For preparatory steps prior to MBS, consensus was reached on the need for comprehensive medical and nutritional evaluations, identifying and correcting all nutritional deficiencies, smoking cessation, and pre-operative endoscopy, with sleep apnea screening only necessary in those considered at high risk. Experts disagreed that routine CT or MRI is required to screen for hepatocellular carcinoma prior to MBS and that all anti-diabetic drugs reduce the risk of this cancer in patients with non-alcoholic fatty liver disease (NAFLD). Table 7 summarizes further results, including anti-COVID 19 steps to take prior to MBS.
Among the 58 experts who performed endoscopic metabolic and bariatric therapy (EMBT), almost unanimous consensus was reached on the unique and important roles these procedures have managing obesity; that adequate endoscopic bariatric training is required for practitioners; and that MBS centers should communicate a comprehensive care plan to patients and their primary care providers, including testing, supplements, and when to be referred back for re-evaluation. Table 8 also specifically summarizes consensus opinions on aspiration therapy, duodenal procedures, endoscopic gastric bypass, gastric plication and suturing procedures, and intragastric balloons (IGBs). Among these, the greatest support was expressed for IGB and least for aspiration therapy and duodenal bypass, with intermediate support expressed for gastric procedures involving bypass, plication, or suturing, depending on the situation. The only procedures for which currently published empirical evidence was considered adequately supportive for them to no longer be considered of uncertain efficacy were those involving balloons. Intragastric balloons also were the only procedures considered acceptable for the sole purpose of helping patients “look better” and were voted acceptable “bridge therapy” for patients scheduled for later MBS.
Regarding post-procedural follow-up and outcomes, unanimous consensus was expressed that some degree of weight regain is normal 2–10 years after MBS, but also that appreciable weight regain may require further medical, endoscopic, or surgical treatment. Experts also unanimously agreed that post-MBS follow-up should be lifelong and that MBS centers should work jointly with patients' primary care providers to provide follow-up and access to appropriate healthcare professionals, as indicated. Near-unanimous agreement was expressed on the potential need for further treatment in patients with continued severe obesity and obesity-related problems two years after MBS, and on the need for comprehensive multi-disciplinary assessments in patients experiencing appreciable post-operative weight regain. Unsatisfactory post-operative weight loss was also considered an indication for supplementary anti-obesity medication (AOM). However, 93.3% and 80.9% agreed, respectively, that no uniformly-recognized definitions exist for either “significant weight regain” or “surgical success.”
For follow-up, nutrition counselling was considered an essential component of post endoscopic treatment by 98.9%, while assessing bone health and ruling out gastroesophageal dysfunction were considered important in patients deemed at high risk for osteoporosis and gastroesophageal reflux disease (GERD), respectively. Consensus agreement also was achieved on several statements pertaining to the benefits of MBS at a societal level. Further results are summarized in Table 9.
Discussion
Clinical management of people with obesity has evolved tremendously over the past decade as understanding of this chronic disease has improved. Such advances include more universal acceptance of obesity as a disease. Despite this, its prevalence continues to rise worldwide in all age groups [2,3,4] as is its economic burden on healthcare systems [32]. In addition, the percentage of patients seeking any form of effective therapy for their obesity remains very low. There is widespread agreement, even beyond the current panel of experts, that a dire need exists to alter obesity’s current world trajectory and find ways to both prevent and treat it in more individuals. Two options that achieved unanimous consensus in our expert panel might achieve both goals: first, for all medical societies to cooperate to address the problem systematically; and second, for longitudinal surveillance to be conducted routinely at both regional and national levels. Two examples of multinational obesity surveillance programs that have generated useful data are the Scandinavian Obesity Registry (SOReg) [33] and German Bariatric Surgery Registry [34], the latter having existed for > 60 years. Such data have generated publications on crucial issues like short-term and long-term outcomes after MBS and a 10-year post-operative mortality rate of just 0.06% over the first 90 post-operative days, as well as data on immediate and longer-term post-operative complications, weight loss, comorbidity management, impact of patient age on outcomes, and comparing different MBS procedures [33,34,35,36,37,38,39,40,41]. Though such data are tremendously valuable, only a very small percentage of individuals with obesity ever undergo MBS, and it is the remaining huge majority for which closer surveillance remains necessary. More realistic, perhaps, are physician and public obesity education campaigns to increase awareness both about the health hazards associated with obesity (e.g., increased risk of cancer), and the need for comprehensive, multidisciplinary treatment, especially for those whose obesity has become severe and/or having obesity-associated comorbidities.
Another issue on which unanimous consensus was repeatedly reached was obesity in children and adolescents, all our experts agreeing that global rates of obesity are currently increasing in youths and that most youths with obesity continue to have obesity in adulthood. Additionally, youths with severe obesity are at risk of significant obesity-related comorbidities like diabetes. Unanimity also was expressed that MBS in adolescents requires an experienced, multi-disciplinary team with experience dealing with youths and their families, and that inadequate physician and public awareness and insufficient long-term outcome data are barriers against the referral of adolescents who might benefit from MBS. Pertaining to insufficient data, five meta-analyses documenting the beneficial effects of MBS in adolescents (including sustained weight reduction, improvements in some obesity-related comorbidities, and improved QoL) have been published [42,43,44,45,46]. However, few studies have had follow-up beyond five years and virtually none followed youths into adulthood. Data also are scant on potential nutritional and developmental difficulties [46].
In our survey, unanimous consensus was reached on five additional statements, all pertaining to surgical treatment or post-surgical follow-up. Unanimously expressed opinions were that multidisciplinary assessment is necessary prior to MBS; that some degree of weight regain is normal from 2 to 10 years after MBS; that significant weight regain, or the presence/persistence of obesity-related medical problems may require further medical, endoscopic, or surgical treatment; that follow-up after MBS should be lifelong; and that MBS centers should work jointly with their patients’ primary healthcare providers to ensure adequate follow-up and access to other healthcare professionals. Regarding MBS patient selection, the pre-operative factors rated very important by almost all experts were the patient’s overall level of health and fitness, presence and/or nature of comorbid illness, cognitive ability to understand the procedure and instructions, and presence of either alcohol or another substance abuse.
Repeatedly expressed was the need for multiple healthcare practitioners spanning different disciplines, especially for patients considering MBS. This should begin with a multi-disciplinary pre-operative assessment to determine each patient’s eligibility. Such assessments also are necessary to identify co-morbid medical, nutritional, and psychological disorders and barriers to treatment success and attempt to address as many of these barriers pre-operatively as possible. Also necessary is to otherwise prepare patients for surgery, including educating them concerning realistic goals, potential post-operative symptoms, high likelihood of some weight regain or other set-backs, and vital importance of continued, life-long follow-up. This multimodal management requires collaboration from members of a multidisciplinary team that includes dieticians/nutritionists, behavioral therapists, physicians, endocrinologists, endoscopists, and surgeons.
Post-operatively, patients continue to require ongoing, multi-disciplinary care to manage their weight loss program and obesity-associated comorbidities. They also require monitoring for the life-altering effects of surgery, like the risk of potentially catastrophic nutritional deficiencies that may vary depending on the specific MBS performed [22, 47]. Each patient’s psychological state must also be followed, given recent data suggesting a slightly elevated risk of suicide in both adolescents and adults who undergo MBS [48, 49]. Potential contributory factors include forced alterations in foods they can and cannot eat, gastrointestinal symptoms secondary to food intolerance, and unrealized, unrealistic expectations about the extent of weight loss they may experience post-operatively, leading to depression, anxiety, reduced sense of self-worth, and other forms of psychological distress. Monitoring also is essential to detect the re-emergence of detrimental eating patterns, like binge eating, as such factors may predict poorer post-operative weight management [50].
Every expert consensus survey has the potential for bias, given that participants may already have a predilection to utilize a particular practice to have become experts in its use. In addition to adopting the Delphi approach (characterized by voter anonymity, largely eliminating acquiescence bias), our survey was unique in that we sought the opinions of a uniquely-broad array of healthcare practitioners that included surgeons, non-surgical physicians, and non-physician experts in nutrition and psychological counselling. All participants were invited to vote on any statement with which they felt comfortable, except for one module on endoscopic therapy restricted to surgeons and endoscopists. Recognizing worldwide differences in obesity management, we also included experts from every permanently inhabited continent. In this manner, we attempted to minimize the widely held criticisms of consensus-survey critics of “like-minded individuals voting together.” We further worded survey statements so a sizeable majority neither favored nor opposed the concept/belief/approach presented, with the remaining statements evenly balanced between favorable and unfavorable. The order of response options also was altered so the most favorable option was listed anywhere from first to last.
We nonetheless acknowledge that consensus surveys are level V evidence, and based upon opinions, rather than experimentally-generated data. That said, all our voters were widely renowned experts in obesity management and, thus, both familiar with such research and particularly qualified to interpret it. In other words, their opinions were based not just upon their extensive experience, but on their expansive knowledge of relevant research. Moreover, as stated initially, this consensus survey was conducted to aid in generating joint IFSO-WGO guidelines, for which over 1000 scientific references have also been utilized to frame the discussion. The consensus opinions we sought to aid in drafting those guidelines were for issues for which existing literature is either non-definitive—requiring appreciable interpretation—or largely lacking, especially on issues that might be particularly difficult to study empirically, like whether EMBT can be justified for aesthetic purposes only.
Since the conclusion of this joint IFSO-WGO Delphi Survey, 2022 ASMBS/IFSO Guidelines on Indications for Metabolic and Bariatric Surgery have been published, and many of those guidelines support our survey results [51].
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Acknowledgements
The authors would like to acknowledge the collaborations from both IFSO and WGO members for their participation in this Delphi study. For IFSO, we would like to thank Manuela Mazzarella, Chief Operating Officer, and for WGO Marissa Lopez, Executive Director.
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Key Points
• International consensus survey on obesity.
• Delphi survey on bariatric surgery, bariatric endoscopy, nutrition, psychology.
• Multidisciplinary management of obesity.
These guidelines are being co-published by Springer Nature (Obesity Surgery, https://doi.org/10.1007/s11695-023-06757-2) and Wolters Kluwer (Journal of Clinical Gastroenterology, https://doi.org/10.1097/MCG.0000000000001916).
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Kow, L., Sharaiha, R.Z., O’Kane, M. et al. Methodology and Results of a Joint IFSO-WGO Delphi Survey of 94 Intercontinental, Interdisciplinary Experts in Obesity Management. OBES SURG 33, 3337–3352 (2023). https://doi.org/10.1007/s11695-023-06757-2
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DOI: https://doi.org/10.1007/s11695-023-06757-2