Abstract
Introduction
In the management of postoperative acute moderate-to-severe pain, opioids remain an important component. However, conventional opioids have a narrow therapeutic index and are associated with dose-limiting opioid-related adverse events (ORAEs) that can result in worse patient outcomes. Oliceridine, a new intravenous µ-opioid receptor agonist, is shown in nonclinical studies to be biased for G protein signaling (achieving analgesia) with limited recruitment of β-arrestin (associated with ORAEs). In two phase 3 randomized controlled studies of patients with moderate-to-severe acute pain following hard or soft tissue surgery, in which analgesia was measured using Sum of Pain Intensity Differences (SPID) from baseline over 48 and 24 h (SPID-48 and -24 respectively, oliceridine at demand doses of 0.1, 0.35, or 0.5 mg was highly effective compared to placebo, with a favorable safety profile compared to morphine. This exploratory analysis was conducted to determine whether the safety benefits seen with oliceridine persisted when adjusted for equal levels of analgesia compared to morphine.
Methods
Presence of at least one treatment-emergent ORAE (based on Medical Dictionary for Regulatory Activities [MedDRA]-coded events: hypoxemia, nausea, vomiting, sedation, pruritus, or dizziness) was used as the composite safety endpoint. A logistic regression model was utilized to compare oliceridine (pooled regimens) versus morphine, after controlling for analgesia (using SPID-48 or SPID-24 with pre-rescue scores carried forward 6 h). This analysis excluded patients receiving placebo and was repeated for each study and for pooled data.
Results
At a given level of SPID-48 or SPID-24, patients receiving oliceridine were less likely to experience the composite safety endpoint. Although not statistically significant at the 0.05 level in the soft tissue model, the odds ratio (OR) showed a consistent numerical trend for oliceridine, being approximately half that observed with morphine in both the hard (OR 0.499; 95% confidence interval [CI] 0.255, 0.976; p = 0.042) and soft (OR 0.542; 95% CI 0.250, 1.175; p = 0.121) tissue studies. Results from the pooled data were consistent with those observed in the individual studies (OR 0.507; 95% CI 0.304, 0.844; p = 0.009).
Conclusion
Findings from this exploratory analysis suggest that at comparable levels of analgesia, patients receiving oliceridine were less likely to experience the composite safety endpoint consisting of ORAEs compared to patients treated with morphine.
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Avoid common mistakes on your manuscript.
Why carry out this study? |
Oliceridine, a new intravenous opioid, is shown in nonclinical studies to be a G protein-biased agonist at the μ-opioid receptor. This preferential activity may result in potent analgesia with reduced recruitment of β-arrestin, a signaling pathway associated with opioid-related adverse events (ORAEs). |
In two randomized, placebo- and active-controlled phase 3 studies, we have previously reported that oliceridine administered via patient-controlled analgesia provided effective analgesia with a favorable safety profile. |
An understanding of the relationship between efficacy and safety is important to assess the benefit–risk profile of a new compound. Randomized clinical trials are typically designed to evaluate efficacy and the statistical analytical methods used may be underpowered to identify any differences on the adverse event profile between treatments. |
Logistic regression offers a framework that allows an estimate of the probability of an adverse reaction associated with a treatment, including the assessment of the strength of association. It is routinely used in the evaluation of post-marketing adverse effects reports to determine association of causality. |
In this exploratory analysis, we utilized the logistic regression method to evaluate the safety of oliceridine when adjusted for equal levels of analgesia compared to morphine using data from the two pivotal randomized clinical trials. The ORAEs of nausea, vomiting, sedation, dizziness, pruritus, and hypoxia, with at least one treatment-emergent adverse event, was used as the composite safety endpoint. |
What was learned from the study? |
The analysis demonstrates that at comparable levels of analgesia, patients receiving oliceridine were less likely to experience the composite safety endpoint consisting of ORAEs compared to patients treated with morphine. |
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Introduction
Nearly 86% of surgical patients report experiencing acute pain during the postoperative period, and 75% of these patients report the pain intensity as moderate to severe [1]. Inadequate control of postoperative pain can have negative consequences, including increased morbidity, impaired physical function and quality of life, slowed recovery, increased length of hospitalization, and increased cost of care [2]. While the use of opioids remains a key component of postoperative pain management [3, 4], in recent years, implementation of Enhanced Recovery After Surgery (ERAS) protocols to optimize patient outcomes have included strategies for decreasing postoperative pain via a multimodal, opioid-sparing approach [4, 5]. However, many multimodal analgesic protocols under the ERAS guidelines have provided inconsistent evidence on postoperative opioid-sparing abilities or adequate pain control [4, 6, 7]. Recent studies also report increased adverse events (AEs) associated with the use of non-opioid strategies [8, 9]. The US Centers for Disease Control and Prevention recommend that in acute postsurgical pain, the benefits of a limited course of opioids may outweigh the risks if pain management is inadequate with non-opioid therapies [10]. Thus, defining the rational use of opioids with a focus on the optimal balance of analgesia with minimal risks is important [11].
Conventional opioids have a narrow therapeutic index and are associated with dose-limiting opioid-related AEs (ORAEs), such as nausea, vomiting, pruritus, constipation, or respiratory depression [12,13,14]. Oliceridine, a new intravenous (IV) opioid, is shown in nonclinical studies to be a G protein-biased agonist at the µ-opioid receptor. This G protein bias may result in analgesia with limited recruitment of β arrestin, a signaling pathway associated with ORAEs [15]. In two randomized, double-blind, placebo- and morphine-controlled studies conducted in patients with moderate-to-severe acute pain following either orthopedic surgery (hard tissue—bunionectomy) or plastic surgery (soft tissue—abdominoplasty), oliceridine administered using patient-controlled analgesia (PCA) at demand doses of 0.1, 0.35, and 0.5 mg was highly effective compared to placebo and had a favorable safety profile [16, 17]. Exploratory analyses indicated that the oliceridine 0.35- and 0.5-mg demand dose regimens were noninferior to morphine.
Measurement of respiratory safety burden (RSB) calculated as the mathematical product of the incidence of a defined set of observed respiratory safety events (RSE) multiplied by the mean expected cumulative duration of these events (in hours) was a key secondary endpoint in both studies [16, 17]. In both studies, the incidences of the RSE were numerically lower for each of the oliceridine dosage regimens compared to the morphine regimen, although statistical significance was not reached. Also, the overall rate of the RSEs was lower than expected in all the treatment groups (oliceridine, morphine, and placebo regimens), possibly resulting in a reduced statistical power to detect any significant differences between treatment [16, 17]. In both studies, spontaneously reported AEs were assessed during the randomized treatment and 7-day follow-up period, and coded using the Medical Dictionary for Regulatory Activities (MedDRA), version 19.0 [16, 17]. In the bunionectomy trial (hard-tissue model), the overall reported incidence of AEs ranged from 73.7 to 91.1% in the oliceridine treatment regimens and was 96.1% in the morphine group and 68.4% in the placebo group. Similar findings were observed in the abdominoplasty study (soft-tissue model), with the reported incidence of overall AEs ranging from 89.6 to 95.0% in the oliceridine treatment regimens, and 97.6% in the morphine group and 78.3% in the placebo group. In both studies, the most common treatment-emergent AEs (reported in ≥ 10% of patients) in any treatment group were nausea, vomiting, dizziness, headache, constipation, pruritus, and hypoxia.
An understanding of the relationship between efficacy and safety is important to assess the benefit–risk profile. Typically, in a randomized clinical trial (RCT), the statistical analytical methods to evaluate efficacy are well established but this is not the case for adverse drug reactions [18]. One of the challenges in applying statistical analysis to AEs is that RCTs are typically designed to evaluate efficacy and the statistical analytical methods used are underpowered to detect differences in AEs between treatments—unless it is a “predefined” measure [18, 19]. In any RCT, spontaneously reported AEs are typically collected and reported as descriptive measures. The descriptive summaries provide information on the “detecting signals” of AEs [19] but do not allow comparison between treatments.
Logistic regression offers a framework that allows an estimate of the probability of an adverse reaction associated with a treatment, including the assessment of the strength of association, and is routinely used in the evaluation of post-marketing AE reports to determine association of causality [20, 21]. Based on findings from a phase 1 study and a fixed-dose phase 2 study, an initial 1 mg dose of oliceridine is approximately equipotent to morphine 5 mg [22, 23]. However, the dose equivalency of oliceridine to morphine after cumulative dosing has not been established. Thus, in this analysis, we utilized the logistic regression method to evaluate the safety of oliceridine when adjusted for equal levels of analgesia (as measured by Sum of Pain Intensity Differences [SPID]) compared to morphine using data from the two pivotal RCTs, APOLLO-1 (orthopedic surgery—bunionectomy) [17] and APOLLO-2 (plastic surgery—abdominoplasty) [16]. The findings from this exploratory analysis are reported here.
Methods
The study design and the results of the randomized, double-blind, placebo- and morphine-controlled studies following either orthopedic surgery (hard-tissue model—bunionectomy) or plastic surgery (soft-tissue model—abdominoplasty) were previously described [16, 17] (See Electronic Supplementary Material Fig. 1: Study designs of the phase 3 pivotal trials). Both studies were conducted in compliance with the protocol and regulatory requirements consistent with the International Council on Harmonization Good Clinical Practice Guidelines and the ethical principles of the Declaration of Helsinki. The study was approved by an Institutional Review Board at each investigational site, and patients provided written informed consent before participation. Advarra Inc. (Columbia, MD, USA) provided a centralized institutional review board approval for all sites.
Although similar in design, these two studies differed in their use of anesthetics (regional anesthesia with popliteal sciatic nerve block in the bunionectomy study and general anesthesia with the use of fentanyl and propofol in the abdominoplasty study), time from surgery to the first dose of study medication, temporal courses of pain after discontinuation of anesthesia (within 9 h after discontinuation of regional anesthesia in the bunionectomy study, and within 4 h after surgery and at least 20 min after the last dose of fentanyl in the abdominoplasty study), qualifying numerical rating scale (NRS) pain intensity scores, and duration of the randomized treatment period (48 h for the bunionectomy study and 24 h for the abdominoplasty study).
In both studies, patients aged 18–75 years, with a body mass index ≤ 35 kg/m2 and body weight ≥ 40 kg, who underwent primary surgery of either bunionectomy (orthopedic surgery) or abdominoplasty (plastic surgery) and experienced moderate-to-severe pain as measured by the NRS (≥ 4 for the bunionectomy study and ≥ 5 for the abdominoplasty study) were enrolled. Patients were randomized to receive IV demand dose regimens of either placebo, oliceridine 0.1 mg, oliceridine 0.35 mg, oliceridine 0.5 mg, or morphine 1 mg. For each regimen, a clinician administered a fixed IV loading dose (oliceridine 1.5 mg, morphine 4 mg, or volume-matched placebo) followed by demand doses administered via a PCA device and blinded supplemental doses. PCA doses were allowed from 10 min after the loading dose and limited by a 6-min lockout interval. Blinded clinician-administered IV supplemental doses (oliceridine 0.75 mg and morphine 2 mg) were permitted as often as hourly as needed (PRN). The dosing limit for all groups was three PCA syringes or six clinician-administered supplemental PRN doses within the first 12 h (60 mg for the oliceridine group). Patients reaching this dosing limit were discontinued, managed with conventional therapies, and allowed to remain in the study as non-responders.
In both studies, RSB experienced by patients in each treatment group, calculated as the mathematical product of the incidence of a defined set of observed RSEs multiplied by the mean expected cumulative duration of these events (RSB; in hours), was a prespecified endpoint and findings have been previously reported [16, 17].
Both studies also reported overall safety and tolerability assessed via the occurrence of treatment-emergent AEs that were spontaneously reported during the randomized treatment and 7-day follow-up period, coded using MedDRA, version 19.0. For this exploratory analysis, the spontaneously reported MedDRA events, in particular, events that occurred in ≥ 10% of patients in any treatment group of oliceridine or morphine, was utilized. Patients receiving placebo were excluded from the analysis. The ORAEs (MedDRA-coded events) of nausea, vomiting, sedation, dizziness, pruritus, and hypoxia, with at least one treatment-emergent AE, was used as the composite safety endpoint. The AEs of oliceridine and morphine, adjusted for therapeutic effectiveness (analgesia as measured by SPID is held constant across treatment groups) were compared by logistic regression.
Statistical Methodology
In the logistic regression model, the presence of at least one treatment-emergent AE as mentioned above (the composite safety endpoint) was defined as “Yes”; and absence of the AE was designated as “No.” Analgesia was determined utilizing the SPID-48 (SPID from baseline over 48 h) for the bunionectomy (hard-tissue surgery) and SPID-24 (SPID from baseline over 24 h) for the abdominoplasty (soft-tissue surgery) studies. For patients who received rescue analgesics (etodolac 200 mg every 6 h [q6h] as needed), the pre-rescue pain score was used instead of the pain scores measured after rescue medication usage for 6 h. This imputation was utilized in the calculation of the SPID score.
The logistic regression model included the effects of treatment, baseline pain score, and SPID-48/SPID-24. This analysis was done for both individual studies as well as on the pooled data. Interaction terms were included to explore the consistency of the effect across treatment groups. For the individual studies, the composite safety endpoint was the dependent variable, with treatment, baseline pain score, SPID-48 or SPID-24, and the interaction terms of treatment by baseline pain score, treatment by SPID-48/SPID-24, and baseline pain score by SPID-48/SPID-24 as explanatory variables. For the pooled data, the logistic regression model included the same dependent variable (composite safety endpoint) and all of the explanatory variables as for the individual studies, with the addition of study indicator interactions into the model. Additional interaction terms utilizing the study indicator were added to explore the consistency of the effect across the two studies. For ease of interpretation, treatment groups were dichotomized since patients could achieve the same amount of oliceridine despite the demand dose regimen. In the model, oliceridine demand dose regimens of 0.1, 0.35, and 0.5 mg were pooled and set as “zero” and morphine treatment regimen was set to “one.” A backward elimination methodology was utilized across all analyses using the p ≤ 0.15 criteria for determining the final model.
For the individual studies, we also evaluated the effects of treatment when adjusted for equal levels of analgesia on the AEs of nausea, vomiting, sedation, dizziness, pruritus, and hypoxia.
Results
The incidence of spontaneously reported MedDRA events (nausea, vomiting, sedation, dizziness, pruritus, and hypoxia) used in the composite endpoint in any of the oliceridine or morphine treatment groups by study is shown in Table 1.
Composite Safety Endpoint
The odds ratio (OR) for the logistic regression model for individual studies and pooled data is shown in Table 2. The OR with its associated 95% confidence interval (CI) for the effect of treatment were 0.499 (95% CI 0.255, 0.976) and 0.542 (95% CI 0.250, 1.175) in the bunionectomy and abdominoplasty studies, respectively (Fig. 1). In the abdominoplasty study, the effect of baseline pain score on the composite safety endpoint was also statistically significant at the 0.05 alpha level (OR 1.279; 95% CI 1.037, 1.576). The findings from the individual studies suggest that at any given level of SPID-48 or SPID-24, the OR for the oliceridine composite safety endpoint was approximately half of that observed with morphine (Table 2; Fig. 1). In the pooled data, the OR estimate was 0.507 (95% CI 0.304, 0.844) for the treatment effect (Table 2; Fig. 1).
Individual ORAEs
The influence of treatment effect on the individual ORAEs of nausea, vomiting, sedation, dizziness, pruritus, and hypoxia for the individual studies are shown in Fig. 2. In the bunionectomy study, the OR was lower (OR < 1) for five of six individual AEs, with favorability towards oliceridine over morphine for nausea, vomiting, and pruritus; the ORs (95% CIs) for these latter three AEs were 0.544 (0.308, 0.964), 0.464 (0.268, 0.804), and 0.319 (0.150, 0.674) (Fig. 2). In the abdominoplasty study, the ORs were lower for all of the six individual AEs with oliceridine versus morphine, with favorability towards oliceridine for nausea (OR 0.526; 95% CI 0.289, 0.959), vomiting (OR 0.351; 95% CI 0.208, 0.595), and sedation (OR 0.385; 95% CI 0.195, 0.762) (Fig. 2).
Discussion
Oliceridine is structurally distinct from natural opiates (e.g., morphine) and from its semi-synthetic derivatives (e.g., hydromorphone) [24]. The development of oliceridine stemmed from the concept that a G protein-biased ligand with reduced β-arrestin recruitment might offer increased analgesia with improved safety and tolerability [25]. Although preclinical findings support the hypothesis of “biased agonist” [15, 26], the translation of these findings in humans has not been fully established. In a clinical setting, when the aim is to manage moderate-to-severe acute pain, what is important is the availability of good analgesic efficacy with a favorable side effect profile [27]. Using the logistic regression model, the findings from the individual studies suggest that at any given level of SPID-48 or SPID-24, the OR for oliceridine on the composite safety endpoint was approximately half of that observed with morphine. The results from the analysis of the pooled data were consistent with the findings from individual studies and show that, at any given SPID-48/-24, patients receiving oliceridine were less likely to experience the defined safety composite endpoint. Findings from this exploratory analysis suggest that under equianalgesic conditions, oliceridine has a favorable risk–benefit profile when compared to morphine.
In both of the pivotal RCTs [16, 17], findings from exploratory analyses indicated that the oliceridine 0.35 mg and 0.5 mg demand doses were noninferior to the morphine 1 mg demand dose. The most common AEs reported in both these trials were mild to moderate in intensity, and the incidence of AEs leading to early study medication discontinuation was low [16, 17]. The composite safety endpoint included in this analysis was the most common AEs reported in ≥ 10% of patients and included nausea, vomiting, sedation, dizziness, pruritus, and hypoxia. Among these events, the reported incidence of hypoxia was < 10% in the bunionectomy study, with rates reported in 5% of patients with the oliceridine 0.35 mg demand dose regimen and in 9% of patients with the oliceridine 0.5 mg and morphine 1 mg demand dose regimens, respectively. Thus, in the bunionectomy study the contribution of hypoxia to the overall composite safety endpoint appears to be minimal. The incidence of sedation/somnolence, although similar for oliceridine in both phase 3 randomized controlled studies, was higher for morphine in the abdominoplasty study than in the bunionectomy study. In the bunionectomy study the incidence of sedation/somnolence for morphine was comparable to that for the oliceridine treatment and, consequently, the logistic regression model did not show a treatment difference; in contrast, in the abdominoplasty study a treatment effect in favor of oliceridine was observed.
Analysis of the individual AEs did show that nausea and vomiting were the most common AEs in both studies, contributing to the significant treatment difference between oliceridine and morphine. In another earlier exploratory analysis on an endpoint of complete gastrointestinal (GI) response defined as “no vomiting and no use of rescue medication,” we reported that when controlled for the analgesic effects (constant SPID-48/-24), the odds of achieving a complete GI response was higher with oliceridine than with morphine, suggesting better GI tolerability with oliceridine [28]. The findings from this analysis further confirm a favorable benefit–risk profile for oliceridine as it relates to the AEs of nausea and vomiting. Of note, in both of these randomized controlled clinical studies [16, 17], the majority of the enrolled patients had an Apfel score ≥ 3 (with similar distribution across treatment arms), indicating a high risk for postoperative nausea and vomiting (PONV). The guidelines for the management of PONV also recommend use of three to four prophylactic antiemetics in patients with > 2 risk factors. Both of the randomized controlled clinical trials did not permit the use of any prophylactic antiemetics. Thus, the findings of a favorable risk profile with oliceridine is compelling.
There are certain limitations to our analysis. The analysis is exploratory in nature and the findings are post-randomization. The AEs collected were spontaneously reported, and a formal assessment of the AEs included in the composite safety endpoint was not conducted. Incorporating objective statistical methods helps to assist the evaluation of AE information to better identify benefit–risk relationships [18].
Conclusions
The findings from this exploratory analysis suggest that when analgesia (as measured by SPID-48 and SPID-24) is held constant across treatment groups, patients receiving oliceridine were less likely to experience AEs compared to patients treated with morphine. In both studies, the OR for the composite safety endpoint with oliceridine was approximately half of that observed with morphine. Findings from the analysis show that under equianalgesic conditions, oliceridine has a favorable risk–benefit profile compared to morphine.
Change history
05 November 2021
A peer-reviewed video was retrospectively added to this publication.
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Acknowledgements
The authors wish to thank Kanaka Sridharan, M.S., R.Ph., an employee at Trevena Inc., for editorial assistance and creation of the figures.
Funding
The studies included here in the exploratory analyses (orthopedic surgery—bunionectomy, APOLLO-1; ClinicalTrials.gov Identifier: NCT02815709) and plastic surgery—abdominoplasty, APOLLO-2; ClinicalTrials.gov Identifier: NCT02820324) and the journal’s Rapid Service Fee were sponsored by Trevena, Inc., Chesterbrook, PA, USA. The exploratory analysis described here was also funded by Trevena, Inc.
Authorship
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
Authorship Contributions
Mark A Demitrack and Michael J Fossler provided the concept and design for the analysis, and interpreted the results. Gregory Hammer, Sabry Ayad, Ashish Khanna, and Linda Wase provided inputs to the design of the analysis and interpretation of the results. Roderick Little and Cathy Michalsky performed the statistical analysis. Gregory Hammer, Sabry Ayad, and Ashish Khanna provided direction for the Introduction and Discussion section of the manuscript; Cathy Michalsky drafted the Methods and Results sections. Gregory Hammer, Sabry Ayad, Ashish Khanna, Roderick Little, Mark A Demitrack, Michael J Fossler, and Linda Wase revised the draft critically for scientific content.
Disclosures
Dr. Gregory Hammer and Dr. Sabry Ayad serve in the Speakers’ Bureau. Dr. Roderick Little served as a consultant for Trevena and provided direction to the conduct of the analysis. Dr. Ashish Khanna is a consultant to Trevena, Inc. Linda Wase, Cathy Michalsky, Mark A. Demitrack, and Michael J. Fossler, are full-time employees and stockholders of Trevena Inc.
Compliance with Ethics Guidelines
All procedures performed in the studies were conducted in accordance with the International Conference on Harmonization Good Clinical Practice guidelines and ethical principles that have their origin in the Declaration of Helsinki. The study was approved by an Institutional Review Board at each investigational site, and patients provided written informed consent before participation. Advarra® provided a centralized institutional review board approval for all sites. Informed consent was obtained from all individual participants included in the study, as specified in the APOLLO-1 and APOLLO-2 studies.
Data Availability
The data sets generated during and/or analyzed during the current study are available from Trevena, Inc. on reasonable request.
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Hammer, G.B., Khanna, A.K., Michalsky, C. et al. Oliceridine Exhibits Improved Tolerability Compared to Morphine at Equianalgesic Conditions: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials. Pain Ther 10, 1343–1353 (2021). https://doi.org/10.1007/s40122-021-00299-0
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DOI: https://doi.org/10.1007/s40122-021-00299-0