Abstract
Functional impairment remains one of the most challenging issues for treatment in schizophrenia. However, previous studies have mainly focused on the negative impact of symptoms excluding variables that could positively impact functional outcome, such as creativity, which is considered an adaptive capacity for real-life problem-solving. This study analyzed the predictive role of creativity on functional outcome in 96 patients with schizophrenia through a mediational model, including sociodemographic, clinical, neurocognitive, and social cognitive variables. Path analysis revealed that creativity significantly mediated the relationship between neurocognition and functional outcome, and that creativity mediated between negative symptoms and functional outcome. Additionally, neurocognition was directly associated with functional outcome and social functioning was associated with creativity. The involvement of creativity in functional outcome could have relevant implications for the development of new interventions. These findings open up a new field of research on additional personal resources as possible factors of functional outcome in schizophrenia and other diseases.
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Introduction
In spite of advances in pharmacological and psychological treatments, schizophrenia is still considered one of the most disabling disorders in the world1. Patients with schizophrenia experience difficulties in a variety of daily life functioning domains, mainly in independent living, occupational functioning, and social functioning2. This functional impairment not only affects the patients’ quality of life, but also has indirect effects on their relatives and caregivers3. Furthermore, this impairment leads to a very high financial cost4. For all these reasons, it is necessary to correctly identify the factors that hinder functional outcome in this disease in order to establish better potential treatment targets. Indeed, in the last two decades, there has been a burst of interest in studying factors underlying functional impairment of people with schizophrenia4. The main factors that have been proposed are cognitive impairment and severity of clinical symptoms5,6,7,8,9.
Regarding clinical symptoms, both negative and positive symptoms have been related to functional outcome1,10,11, although the former seems to have a greater impact6,12,13,14. Moreover, primary negative symptoms seem to contribute to functional outcome after controlling for secondary negative symptoms such as those related to medication10. Specifically, motivational deficits have shown to be the most robust predictors of functional outcome15. Another clinical factor that has also been related to functional outcome is disorganization, which is closely related to neurocognition1.
With respect to cognition, cognitive deficits in neurocognition and social cognition seem to be a core feature of this disease16. Numerous studies have shown that cognitive functioning is a main predictor of functional outcome in schizophrenia1,6,8,9,17,18,19,20. Interestingly, a meta-analysis carried out by Fett et al.21 found that social cognition had a stronger involvement in functional outcome than neurocognition. Furthermore, evidence from several studies suggests that social cognition could act as a mediator between neurocognition and functional outcome1,22,23,24. Additionally, clinical symptoms, mainly negative symptoms, have also been suggested to mediate between cognition and functional outcome6,12,13.
Besides these clinical and cognitive factors, it has been suggested that other kinds of personal resources could also be important determinants of real-life functioning1,11. In particular, creative capacity could be crucial for functional outcome in schizophrenia25. Creativity consists of the capacity to produce something original or novel and appropriate or useful for a task26. Evidence from studies carried out in the general population indicates that creativity is a key component for real-life problem-solving27 and it is considered an essential resource for adaptation and coping with daily life adversities in healthy people28,29. This capacity increases the ability to perform everyday activities through the application of creative problem-solving skills to daily life problems30. Moreover, creativity applied to our daily life has been shown to improve individuals’ physical and psychological health as well as self-competency, life satisfaction, social life, civil participation, and academic and job performance31,32,33. Regarding creativity in schizophrenia, a recent meta-analysis indicates that people with this disease show a worse creative performance than the general population34. Nemoto et al.25 found higher creativity to be related to better functional outcome in schizophrenia. Specifically, these authors found that verbal creativity (measured through an idea fluency test)35 was related to daily living and community functioning and figural creativity (measured through a design fluency test)35 was associated with interpersonal relations and community functioning25. In this study, in addition to creativity, negative symptoms and general psychopathology predicted functional outcome, but not neurocognition25. In another study, nonverbal creativity was related to different coping strategies within schizophrenia spectrum and bipolar disorder36. Additionally, in a pilot study, a creativity intervention was shown to improve negative symptoms, creativity, general psychopathology, global functioning, and interpersonal relations37. Likewise, research carried out among the elderly and people with bipolar disorder have suggested that creativity may act as a compensatory advantage for better daily functioning and well-being31,32. Thus, evidence suggests that those patients with schizophrenia who have better creative skills may possibly benefit from this resource for better and more adaptive daily life functioning.
Although creativity has been defined as a complex multidimensional construct, it is not a completely independent variable in schizophrenia. Previous literature suggests that creativity is closely related to neurocognition and social cognition in schizophrenia38,39,40,41,42. Specifically, both social cognition and neurocognition have been shown to play a mediatory role in the relationship between creativity and schizophrenia40. Additional evidence comes from studies that have found the metacognitive ability (which is related to creative thinking)43,44 to be associated with functional outcome in schizophrenia45,46 as well as to mediate the relationship between neurocognition and functional outcome in this disease47. In addition to cognition, clinical symptoms, specifically negative symptoms, have also been shown to predict creativity39,41.
Altogether, the literature suggests that functional outcome in schizophrenia may be explained not only by factors such as clinical symptoms and cognitive impairment, but also by other factors like creative ability. However, as far as the authors are aware, to date no study has explored the predictive value of creativity on functional outcome in this disease through a mediational model including clinical symptoms, neurocognition, and social cognition. Therefore, the aim of this study was to analyze the contribution of creativity in functional outcome of patients with schizophrenia through a mediational model analyzing the interplay of clinical symptoms, neurocognition, social cognition, and creativity when explaining their contribution to functional outcome. Based on previous evidence, it was hypothesized that creative capacity would be associated with functional outcome, mediating the association between neurocognition, social cognition, negative symptoms, and functional outcome in schizophrenia.
Results
The average performance scores on clinical, neurocognitive, social cognitive, creativity, and functional outcome tests are shown in Table 1. To check the association between sociodemographic data and the rest of the variables of the study, correlation analyses were performed (Table 2). Additionally, correlations between neurocognitive individual domains, social cognitive domains, creativity, and functional outcome are shown in Supplementary Table 1. Several statistically significant associations were found. Regarding sociodemographic variables, sex (being female) correlated significantly and negatively with negative symptoms (rpb = −0.261, p = 0.010) and excitement (rpb = −0.237, p = 0.020). Age correlated significantly and negatively with neurocognition (r = −0.386, p < 0.001) and social cognition (r = −0.334, p = 0.001), and positively with duration of illness (r = 0.856, p < 0.001). Finally, years of education correlated significantly and negatively with disorganization (rs = −0.260, p = 0.010) and excitement (rs = −0.221, p = 0.031), and positively with neurocognition (rs = 0.317, p = 0.002) and social cognition (rs = 0.254, p = 0.013).
Additionally, correlations between clinical characteristics, neurocognition, social cognition, creativity, and functional outcome were performed (Table 3). As can be seen, functional outcomes correlated positively and significantly with neurocognition (r = 0.244, p = 0.017) and figural creativity (r = 0.270 p = 0.008).
Mediational model explaining functional outcome
A model with path analysis was estimated based on previous literature1,22,24,40 and including only paths between the predictors and the mediating or outcome variables that had correlated significantly in the previous analyses. Therefore, positive symptoms, excitement, depression, figural strengths, and verbal creativity were not included in the model. Since sex, age, years of education, and duration of illness correlated significantly with several predictors, these were entered in the model. The fit of the model was very good, SB χ2 (28, N = 96) = 32.162, Comparative Fit Index (CFI) = 0.974, Non-Normed Fit Index (NNFI) = 0.959, and Standard Residual Mean Square Root (SRMR) = 0.061.
As some of the associations were not statistically significant (the paths from age, years of education and disorganization to social cognition, and the covariance between disorganization and negative symptoms), a new model was estimated only with significant paths. The final model obtained is presented in Fig. 1. As can be seen, on the one hand, neurocognition was positively associated with figural creativity and social cognition, and figural creativity was positively associated with functional outcome. Additionally, social cognition and figural creativity were positively related to each other. On the other hand, negative symptoms were negatively related to figural creativity. Finally, neurocognition was also directly and positively related to functional outcomes. The fit of the model was also very good, SB χ2 (32, N = 96) = 40.445, CFI = 0.954, NNFI = 0.936, and SRMR = 0.073. Next, the significance of the mediational paths was examined via 5,000 bootstrapping samples. The results indicated that figural creativity acted as mediating variable between neurocognition and functional outcome (0.340; 95% confidence interval [0.332, 0.350]) and that figural creativity mediated between negative symptoms and functional outcome (−0.020; 95% confidence interval [−0.021, −0.020]).
In addition, an alternative model was tested in which figural creativity mediated between neurocognition, social cognition, and functional outcome. The Satorra-Bentler’s scaled chi-square difference test48 showed that there were not statistically significant differences between the two models [ΔSB χ2 difference (1, N = 96) = 0.233, p = 0.629]. Although there were not statistically significant differences and the fit indexes where very similar, only the first model was included in the current study.
Discussion
The aim of this study was to analyze the predictive value of creativity on functional outcome through a mediational model including sociodemographic, clinical, neurocognitive, social cognitive, creativity, and functional outcome variables. To our knowledge, this is the first study analyzing the mediatory role of creativity on functional outcome of patients with schizophrenia. As hypothesized, creativity was significantly associated with functional outcome. More specifically, figural creativity acted as mediator between neurocognition and functional outcome as well as between negative symptoms and functional outcome. Additionally, neurocognition was directly associated with functional outcome. Moreover, although social cognition was not directly related to functional outcome, it was associated with figural creativity and neurocognition. However, contrary to what was expected based on previous literature1,6,10, negative symptoms were not directly related to functional outcome and cognitive functioning.
The association found between creativity and functional outcome supports the idea that creative problem solving skills are also applied to real-life problems27,30 and therefore, are crucial for daily life functioning. Hence, our findings suggest that patients with schizophrenia who have better creative skills may benefit from this resource to better adapt and cope with their multiple adversities in daily life functioning. As indicated by several authors31,32, creativity can be an adaptive ability capable of improving individuals’ both physical and psychological health. In line with our results, few studies have suggested that creativity could influence the functional outcome of individuals with schizophrenia25, bipolar disorder31, and elderly people32.
As expected, creativity was related to neurocognition and social cognition, and mediated the relationship between neurocognition and functional outcome. The association between neurocognition and social cognition with creativity is consistent with previous research carried out in this pathology38,39,40,41. Similar to this study, another capacity that is related to creativity43,44, metacognition capacity, has also been shown to mediate the relationship between neurocognition and functional outcome in schizophrenia47.
With respect to the association between cognition and functional outcome, in line with previous studies, neurocognition was strongly associated with functional outcome6,9,17,18,19. However, contrary to other studies1,23,24, this association was not mediated by social cognition. In fact, neurocognition was found to be both directly related to functional outcome and through figural creativity. The reason for this may have been that in this study, unexpectedly, social cognition was not directly associated with functional outcome, which could have made the association between neurocognition and functional outcome stronger. A large number of studies have shown a strong relationship between social cognition and functional outcome1,21,22,23,24. Nevertheless, as in this study, other studies have also found an association between neurocognition and functional outcome, but not with social cognition9,19. This may be due to the particular test employed for the measurement of functional outcome. Being a reduced version of the original scale, functional outcome may not have been measured as comprehensively as in other studies1,23. Despite the lack of significant results, social cognition should not be underestimated as it has been shown to be a relevant predictor of functional outcome1,21,22,23,24.
Regarding clinical symptoms, negative symptoms were negatively related to creativity, showing an indirect association with functional outcome through the mediating role of creativity. Other studies carried out on schizophrenia have also found an association between negative symptoms and creativity39,41. This makes sense, as some negative symptoms such as avolition can make a creativity task particularly difficult. However, no clinical symptoms were directly related to functional outcome, and only disorganization was related to cognitive functioning. This was an unexpected result, as in general, studies have found a positive association between clinical symptoms and functional outcome in schizophrenia; some of them only with negative symptoms6,12, but others with both positive and negative symptoms1,10,11 or with disorganization1. In contrast, very few studies have found little or even no association between symptoms and functional outcome49,50. Additionally, studies have found associations between clinical symptoms and cognitive functioning1,6,12,13. In line with this study, Galderisi et al.1 found an association between disorganization and neurocognition, which makes sense since this clinical variable is related to attentional capacity and abstract thinking. The lack of significant results overall with clinical symptoms in this study may be partly due to the different scales or the different scoring methods used for the assessment of clinical symptoms and functional outcome across studies. In fact, some of the studies that have used the same scales as in this study have employed a different scoring method1,11,13,51. For instance, Bechi et al. used the Positive and Negative Syndrome Scale (PANSS) to assess clinical symptoms, but employed a different scoring method51. Galderisi et al.1 did use the same scoring method for the positive symptoms and disorganization, but not for the negative symptoms and they used different measures for functional outcome.
Taken together, findings from this study support the well-known idea that cognitive functioning contributes to functional outcome in schizophrenia and point out the specific role of creativity in this association. Additionally, these results also support the association between negative symptoms and functional outcome through creativity. As Richards stated, in the face of adversity, humans have the potential for resilient creative responses31. Thus, creativity seems to be a key capacity for the performance of daily life activities and for dealing with real-life challenging situations. These results mark an important milestone and open a new window to future lines of research that could explore other possible factors as determinants of functional outcome in schizophrenia. Indeed, research should not only focus on the negative aspects of the disease, such as clinical symptoms or cognitive impairment, as possible predictors of functional outcome, but there should be a shift towards positive psychology. In fact, in addition to creative capacity, other resources such as resilience or positive humor should be taken into account when studying functional outcome. Regarding resilience, Galderisi et al. already found that resilience has a relevant implication in real-life functioning among patients with schizophrenia1. This capacity has been closely related to creativity and has even been suggested that creativity is a potential tool to promote resilience52. With respect to humor, this has also been associated with creativity and it is supposed to enhance creativity53. Cai et al. found that a humor intervention had positive effects on different domains such as negative symptoms, depression, and anxiety among patients with schizophrenia, although they did not measure functional outcome54. Furthermore, the involvement of these kinds of resources on functional outcome should not be limited only to the field of psychosis, but to the whole field of psychopathology as well as to the healthy population.
The importance of this study lies in the fact that understanding which factors underlie functional outcome is vital for the development of more efficient treatment programs. Moreover, the identification of mediators of functional outcome is essential, since these, being closer to the outcome of interest, should become the target of interventions16. Specifically, these results provide further evidence for the idea that including training on creative problem-solving skills could be beneficial for the improvement of functional outcome in this disease37. Not only in psychosis, but it is suggested that the training or practice of positive resources such as creativity have a positive impact on personal well-being and quality of life of the general population55,56. Nevertheless, there are multiple ways of improving creativity. For instance, it could be promoted through “creative-training programs” that include problem-solving or divergent thinking exercises37,55. Alternatively, it could be enhanced through creative activities aimed at improving well-being, such as art therapy55. Furthermore, creativity could also be trained indirectly through other kind of interventions such as humor intervention or laughter therapy53, through cognitive remediation57, or by means of transcranial direct current and random noise stimulation58,59,60. In addition, the inclusion of training of positive resources such as creativity or humor in rehabilitation programs could encourage adherence to treatment and motivation, since it may be more interesting for patients. As noted by Cai et al., including training in positive resources could facilitate coping abilities as well as social functioning54. Altogether, evidence suggests that integrated and holistic treatments addressing multiple domains such as neurocognition, social cognition, and creativity as well as negative symptoms should be applied in order to improve real-life functioning in mental disorders. In fact, the use of combined and multidisciplinary treatments could produce better results than applying them individually, as they could be mutually reinforcing.
Several limitations should be considered in this study. First, functional outcome was addressed through a social functioning scale which included the assessment of different dimensions of real-world functioning (e.g., interpersonal relations, independent living, and employment); however, the additional measurement of other domains such as quality of life or a more exhaustive assessment of some domains like vocational functioning would have provided a broader picture of the impact of creativity on functional outcome. Second, since this study aimed to explore the role of creativity on daily functioning, creativity assessment could have included the measure of everyday creativity in addition to the creativity tasks employed. Future studies should include this kind of scales to acquire a greater understanding about its role in functional outcomes. Third, though this study included a multidimensional neurocognitive evaluation, it would be interesting for future research to analyze the role of other additional cognitive domains also impaired in schizophrenia such as visual and auditory perception or visual memory, in order to provide a further understanding of the role of neurocognition in creativity in this disease. Fourth, the sample was unbalanced towards men, which may have affected the interpretation of the results. Nevertheless, sex was entered in the mediational model to control for its possible effect. Fifth, the small sample size limited the statistical power of the mediational analysis and prevented the inclusion of individual cognitive dimensions, thus more studies should be conducted with larger samples and findings from this study need to be interpreted with care. Finally, the cross-sectional design of this study did not allow to test causal relationships, so results from the present study should be considered with caution. Future studies could analyze these possible long-term relationships. Bearing these limitations in mind, we believe that this study provides initial and relevant evidence of the mediational role of creativity in daily life functioning in schizophrenia, which has significant implications on the development of interventions aimed at improving functional outcomes. Furthermore, this study opens up a new field of research on additional personal resources as possible determinants of functional outcome in schizophrenia and other diseases.
Methods
Participants
Ninety-six patients diagnosed with schizophrenia (85 males and 11 females) were recruited from the Psychiatric Hospital of Álava and the Mental Health Network in Álava (Spain). All patients met the diagnostic criteria for schizophrenia according to the Structured Clinical Interview for DSM-V (the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition)61. The mean age of the sample was 41.37 (SD = 10.79) years old and mean years of education was 10.25 (SD = 2.56). 77.08% of the sample were right-handed, 4.16% left-handed, and 18.75% mixed-handed. The 58.3% of the sample were outpatients and 41.7% were inpatients. Mean age of onset of the disease was 22.79 (SD = 5.67), with a mean of previous hospitalizations of 5.84 (SD = 6.31), mean duration of illness of 18.59 (SD = 10.31), and a mean of medication dosage (chlorpromazine equivalent doses - mg/day) of 511.37 (SD = 295.51). The defined daily dose method was used to change medication to chlorpromazine62,63.
Exclusion criteria consisted of: (a) clinical instability (meeting the relapse criteria of Csernansky et al.64); (b) significant changes in the antipsychotic treatment in the previous three months; (c) cognitive impairment secondary to another disease; (d) diagnosis of an active Major Affective Disorder; and (e) diagnosis of Substance Use Disorder (DSM-V)61 including alcohol during the six months prior to study inclusion (with the exception of nicotine). All participants took part voluntarily, providing written informed consent to participate, and they did not receive any monetary reward for taking part in the study. The study protocol was approved by the Clinical Research Ethics Committees of the Autonomous Region of the Basque Country (CEIC-E) in Spain (PI2017044). This study forms part of a larger ongoing project, which is registered in clinicaltrials.gov (NCT03509597).
Measures
Neurocognition
Neurocognition was measured by means of the following tests assessing cognitive flexibility, processing speed, working memory, verbal memory, and inhibition: the number of categories completed and the number of perseverative errors from the Modified Wisconsin Card Sorting Test (M-WCST)65; Word, Color, and Word-Color values from the Stroop Color and Word Test66; the Backward Digit Span subtest from the Wechsler Adult Intelligence Scale-III (WAIS-III)67; the three learning trials and the delayed recall trial from the Hopkins Verbal Learning Test (HVLT version 2)68; and the Symbol-Coding subtest from the Wechsler Adult Intelligence Scale-III67. All these neurocognitive scores were converted into Z-scores based on the sample of the study. Some scores were adjusted so that higher scores indicated better cognitive performance. A neurocognition composite was then obtained using these Z-scores (Cronbach’s alpha = 0.77).
Social cognition
The evaluation of social cognition included the measurement of three domains: theory of mind, social perception, and emotion processing. Theory of mind was assessed by means of the Happé Test “Strange Stories Task”69. Four stories from this test were used. Social perception was measured through the Social Attribution Task-Multiple Choice II (SAT-MC-II)70. Finally, for the assessment of emotion processing, the Spanish adaptation of the Bell Lysaker Emotion Recognition Test (BLERT)71 was used. A composite score of social cognition was obtained from the Z scores of these three tests based on the sample of the study (Cronbach’s alpha = 0.70).
Creativity
Figural and verbal creativity were assessed by means of two subtests from the Torrance Test of Creative Thinking72,73. Figural creativity was measured through the Picture Completion subtest. This task consists of completing ten unfinished pictures by producing as many ideas as possible. The following dimensions were obtained: originality, fluency, flexibility, elaboration, resistance to premature closure, and abstractness of titles. Flexibility was scored using the criteria from the Spanish adaptation of the Torrance Test of Creative Thinking74. Total figural creativity score was calculated through the sum of these six dimensions. In addition, a figural creative strengths score was calculated based on the manual73. Figural creative strengths consisted of 11 criterion-referenced measures: emotional expressiveness, storytelling articulateness, movement or action, expressiveness of titles, synthesis of incomplete figures, unusual visualization, internal visualization, humor, richness of imagery, colorfulness of imagery, and fantasy.
The Unusual Uses subtest was administered in order to assess verbal creativity. In this activity, participants are asked to write as many unusual uses as possible for cardboard boxes. Originality, fluency, and flexibility dimensions were measured. The sum of these three dimensions was used to obtain the total verbal creativity score. Four minutes were given to complete each subtest.
Clinical symptoms
The PANSS75 was used for the assessment of positive symptoms and general psychopathology. Scores for the dimensions “positive symptoms”, “disorganization”, “excitement”, and “depression” were obtained following the consensus 5-factor solution proposed by Wallwork et al.76, which included four, three, four, and three items respectively. As recommended by the NIMH-MATRICS Consensus Statement on Negative Symptoms77,78, negative symptoms were measured through the Brief Negative Symptom Scale (BNSS)79, composed of 13 items.
Functional outcome
Functional outcome was measured using the short Spanish version of the Social Functioning Scale (SFS)80. It consists of a 15-item self-report scale that evaluates different functioning domains including social engagement and withdrawal, interpersonal communication, pro-social activities, independence (competence and performance), recreation, and employment.
Handedness
Handedness was measured through the Edinburgh Handedness Inventory81. The formula (right - left/right + left) was used to calculate handedness consistency and the scores obtained ranged from 100 (wholly right-handed) to −100 (wholly left-handed). Participants who obtained scores ranging from −79 to 79 were considered to be mixed-handed, and those with scores ranging from −100 to −80 or from 80 to 100 to be consistent-handed.
An expert neuropsychologist administered and corrected all the cognitive and creativity tests and clinical symptoms were assessed by expert trained psychiatrists.
Data analyses
Statistical analyses were carried out by IBM SPSS version 26.0 (SPSS Inc., Chicago, USA). Data were tested for normality using the Kolmogorov-Smirnov test. Missing values were imputed using the expectation maximization (EM) algorithm. Spearman´s Rho, Pearson’s r and point-biserial correlations were performed between sociodemographic, clinical, neurocognitive, social cognitive, creative, and functional outcome variables. Significance level was set at 0.05.
To test the mediation hypothesis, path analysis was used with LISREL 9.282. The robust maximum likelihood (RML) method was employed, which requires an estimate of the asymptotic covariance matrix of the variances and covariates of the sample and includes the scaled χ2 Satorra-Bentler index (SB χ2). The goodness of fit of the model was evaluated by CFI, NNFI, and SRMR. According to Hu and Bentler83, CFI and NNFI values higher than .90, and SRMR values smaller than .08 reflect a good fit83. The Satorra-Bentler’s scaled chi-square difference test48 was performed to compare two alternative models, using the specific program designed by Crawford and Henry84.
Reporting Summary
Further information on research design is available in the Nature Research Reporting Summary linked to this article.
Data availability
The data that support the findings of this study are available from the corresponding author on reasonable request. The data are not publicly available due to them containing information that could compromise research participant privacy or consent.
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Acknowledgements
This work was supported by the Spanish Ministry of Economy and Competitiveness (PI16/01022); the Department of Education and Science of the Basque Government (Team A) (IT946‐16); the Fundación Tatiana Pérez de Guzmán el Bueno (to A.S.); and the University of the Basque Country (UPV/EHU) (PIF 19/40 to M.T.E.). The funding agencies had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors thank all the participants and clinical clusters who were involved in the study as well as the English language editing service. Our special thanks to Amaia Ortiz de Zarate and Edorta Elizagárate for all the support in the recruitment and management of patients.
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N.O., N.I.B., J.P., and P.S. designed the study and wrote the protocol. A.S., P.S., N.I.Y., M.T.E., I.H., and C.P. performed the clinical and neuropsychological evaluations. A.S. and J.P. managed the literature searches and undertook the statistical analysis. A.S. and J.P. wrote the first draft of the manuscript. All authors contributed to the writing and revision of the manuscript. All authors have approved the final manuscript.
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Sampedro, A., Peña, J., Sánchez, P. et al. The impact of creativity on functional outcome in schizophrenia: a mediational model. npj Schizophr 7, 14 (2021). https://doi.org/10.1038/s41537-021-00144-5
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DOI: https://doi.org/10.1038/s41537-021-00144-5
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